Sleep Disorder Connect
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Population pharmacokinetic modeling of daridorexant, a novel dual orexin receptor antagonist - PubMed

Population pharmacokinetic modeling of daridorexant, a novel dual orexin receptor antagonist - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36309969/

The analysis aimed at identifying subject-specific characteristics (covariates) influencing exposure to daridorexant and quantification of covariate effects to determine clinical relevance. Data from 13 phase I, two phase II, and...


Relevance: The analysis aimed at identifying subject-specific characteristics (covariates) influencing exposure to daridorexant and quantification of covariate effects to determine clinical relevance.


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Next-day impacts of insomnia

Insufficient sleep has been associated with difficulty focusing, impaired memory, impaired decision-making, and slower reaction times. This underscores the importance of treating and managing insomnia for employability, safety, and quality of life. According to the DSM-5, the diagnosis of insomnia is based not only on nighttime sleep issues but also daytime impairment that can impact a patient’s academic, social or work life. In a recent study, 73% of insomnia patients complained of challenges falling asleep, and 84% experienced issues with daily functioning.

In clinical trials, patients taking daridorexant (Quviviq) 50 mg reported improvements in daytime sleepiness versus placebo as measured by the Insomnia Daytime Symptoms and Impacts Questionnaire (IDSIQ). This improvement started 1 week after the initial administration and continued to improve over time. Statistically significant nighttime improvements versus placebo were also seen in falling asleep faster, staying asleep longer, and increased total time asleep. These results could be promising since many sleep medications are associated with next-day hangover effects.

Why do you think that patients taking daridorexant 50 mg showed a statistically significant reduction in daytime sleepiness vs placebo? What factors may be contributing to this finding?

  • 3yr
    Insomnia is associated with daytime sleepiness, fatigue and inability to focus, Also is associated with increased risk of MVA, especially for long distance drivers. There is increased symptoms of irritable mood Show More
  • 3yr
    Patients showed improvement quality of life, better sleep with no significant side effects .

Show More Comments

  • Saved

made a Post

Next-day impacts of insomnia

Insufficient sleep has been associated with difficulty focusing, impaired memory, impaired decision-making, and slower reaction times. This underscores the importance of treating and managing insomnia for employability, safety, and quality of life. According to the DSM-5, the diagnosis of insomnia is based not only on nighttime sleep issues but also daytime impairment that can impact a patient’s academic, social or work life. In a recent study, 73% of insomnia patients complained of challenges falling asleep, and 84% experienced issues with daily functioning.



In clinical trials, patients taking daridorexant (Quviviq) 50 mg reported improvements in daytime sleepiness versus placebo as measured by the Insomnia Daytime Symptoms and Impacts Questionnaire (IDSIQ). This improvement started 1 week after the initial administration and continued to improve over time. Statistically significant nighttime improvements versus placebo were also seen in falling asleep faster, staying asleep longer, and increased total time asleep. These results could be promising since many sleep medications are associated with next-day hangover effects.



Why do you think that patients taking daridorexant 50 mg showed a statistically significant reduction in daytime sleepiness vs placebo? What factors may be contributing to this finding?


  • 3yr
    Insomnia is associated with daytime sleepiness, fatigue and inability to focus, Also is associated with increased risk of MVA, especially for long distance drivers. There is increased symptoms of irritable mood Show More
  • 3yr
    Patients showed improvement quality of life, better sleep with no significant side effects .

Show More Comments

  • Saved

made a Post

Next-day impacts of insomnia

Insufficient sleep has been associated with difficulty focusing, impaired memory, impaired decision-making, and slower reaction times. This underscores the importance of treating and managing insomnia for employability, safety, and quality of life. According to the DSM-5, the diagnosis of insomnia is based not only on nighttime sleep issues but also daytime impairment that can impact a patient’s academic, social or work life. In a recent study, 73% of insomnia patients complained of challenges falling asleep, and 84% experienced issues with daily functioning.



In clinical trials, patients taking daridorexant (Quviviq) 50 mg reported improvements in daytime sleepiness versus placebo as measured by the Insomnia Daytime Symptoms and Impacts Questionnaire (IDSIQ). This improvement started 1 week after the initial administration and continued to improve over time. Statistically significant nighttime improvements versus placebo were also seen in falling asleep faster, staying asleep longer, and increased total time asleep. These results could be promising since many sleep medications are associated with next-day hangover effects.



Why do you think that patients taking daridorexant 50 mg showed a statistically significant reduction in daytime sleepiness vs placebo? What factors may be contributing to this finding?


  • 3yr
    Insomnia is associated with daytime sleepiness, fatigue and inability to focus, Also is associated with increased risk of MVA, especially for long distance drivers. There is increased symptoms of irritable mood Show More
  • 3yr
    Patients showed improvement quality of life, better sleep with no significant side effects .

Show More Comments

  • Saved

made a Post

Next-day impacts of insomnia

Insufficient sleep has been associated with difficulty focusing, impaired memory, impaired decision-making, and slower reaction times. This underscores the importance of treating and managing insomnia for employability, safety, and quality of life. According to the DSM-5, the diagnosis of insomnia is based not only on nighttime sleep issues but also daytime impairment that can impact a patient’s academic, social or work life. In a recent study, 73% of insomnia patients complained of challenges falling asleep, and 84% experienced issues with daily functioning.



In clinical trials, patients taking daridorexant (Quviviq) 50 mg reported improvements in daytime sleepiness versus placebo as measured by the Insomnia Daytime Symptoms and Impacts Questionnaire (IDSIQ). This improvement started 1 week after the initial administration and continued to improve over time. Statistically significant nighttime improvements versus placebo were also seen in falling asleep faster, staying asleep longer, and increased total time asleep. These results could be promising since many sleep medications are associated with next-day hangover effects.



Why do you think that patients taking daridorexant 50 mg showed a statistically significant reduction in daytime sleepiness vs placebo? What factors may be contributing to this finding?


  • 3yr
    Insomnia is associated with daytime sleepiness, fatigue and inability to focus, Also is associated with increased risk of MVA, especially for long distance drivers. There is increased symptoms of irritable mood Show More
  • 3yr
    Patients showed improvement quality of life, better sleep with no significant side effects .

Show More Comments