Conclusions/Relevance: Subjective testing with tools, such as sleep logs and sleepiness scales, are often helpful in the evaluation of these disorders but do not necessarily correlate well with objective testing, such as polysomnography and multiple sleep latency test and maintenance of wakefulness test.

Conclusions/Relevance: The proposed mechanism was substantiated using an N-methylated analogue, which might hydrolyze to the open-chain aldehyde but cannot undergo the final cyclization step. CYP3A4 was the major P450 enzyme responsible for daridorexant metabolism, accounting for 89 % of metabolic turnover.

Conclusions: Narcolepsy is a chronic, disabling neurological disorder characterised by daytime sleepiness and recurrent episodes of muscle weakness (cataplexy). It is an under-recognised and under-diagnosed condition with a mean interval of up to 15 years between first presentation to medical care and diagnosis. As narcolepsy is eminently...

Conclusions: The data indicate that elevated glutamate in the ACC could provide a neurochemical mechanism underlying SXB's pro-vigilant efficacy in disorders of hypersomnolence.

Conclusions: Impaired recognition accuracy and longer reaction times were identified in FER tasks among people with insomnia compared to the healthy controls.