Discovery of New Transmitter Systems and Hence New Drug Targets
Source : https://link.springer.com/chapter/10.1007/978-3-031-21054-9_7
The development of medications used to treat psychiatric conditions has largely proceeded through serendipity, where a potential drug to treat mental illness is identified by chance. This approach is based...
Conclusions/Relevance: This chapter will discuss challenges in psychiatric drug development; the importance of identifying discrete neurotransmitter systems that target a specific symptom, not a syndrome; the orexin pathway and targets within this pathway that can be used to modulate sleep; and a high-throughput approach to streamlining drug...
Dynamic observation and qualitative analysis of a psychological crisis hotline during the COVID-19 pandemic
Source : https://www.frontiersin.org/articles/10.3389/frhs.2022.968025/full
ObjectiveThe aim of this study was to analyze the chief complaints of psychological crisis hotlines during the coronavirus disease 2019 (COVID-19) pandemic in Jiangsu, China, and to summarize the psychological...
Conclusions/Relevance: The monthly main complaints showed a fluctuating trend, and each main complaint peaked at different stages. The main complaints during the three stages had distinct features, respectively, and the proportions of calls for the specific complaints differed statistically over the phases.
Factors Associated with Prescriptions for an Orexin Receptor Antagonist Among Japanese Patients with Insomnia: Analysis of a Nationwide Japanese Claims Database - Drugs - Real World Outcomes
Source : https://link.springer.com/article/10.1007/s40801-023-00356-4
Background Few studies have examined the prescribing patterns of orexin receptor antagonists (ORAs) in the real-world clinical setting in Japan. Objective We sought to analyze the factors associated with ORA...
Conclusion: This is the first study to determine the factors associated with ORA prescriptions in Japan. Our findings could help guide appropriate insomnia treatment using ORAs.
Positive airway pressure therapy for post-stroke sleep disordered breathing: a systematic review, meta-analysis and meta-regression
Source : https://err.ersjournals.com/content/32/167/220169
Background Sleep disordered breathing (SDB) is an under-recognised independent risk factor and a potential consequence of stroke. We systematically reviewed and meta-analysed the effectiveness of positive airway pressure (PAP) therapy...
Conclusions: Post-stroke patients with SDB benefited from PAP therapy. Prospective trials are needed to determine the ideal initiation period and the minimum effective therapeutic dose.
-
Neurologist Connect3yrKey Points • Source: European Respiratory Review • Conclusions “Post-stroke patients with SDB [sleep-disordered breathing] benefited from PAP [positive airway pressure] therapy. Prospective trials are needed to determine the ideal initiation period and the Show More
Study of the Effects of Melatonin on Sleep Disorders in Pulmonary Sarcoidosis Patients
Source : https://brieflands.com/articles/ijpr-132168.html
Faezeh Feizabadi 1 , Atefeh Abedini 2 , Jamshid Salamzadeh 1 , Saghar Barati 1 , Farzaneh Dastan 1 ,2 ,* 1 Department of Clinical Pharmacy, School of Pharmacy, Shahid...
Conclusions: Our findings showed that supplemental melatonin could significantly improve sleep problems, quality of life, and excessive daytime sleepiness in sarcoidosis patients.