Metabotropic glutamate receptor function and regulation of sleep-wake cycles
Source : https://www.sciencedirect.com/science/article/abs/pii/S0074774222001416?via=ihub
Metabotropic glutamate (mGlu) receptors are the most abundant family of G-protein coupled receptors and are widely expressed throughout the central ne...
Conclusions: In addition to reviewing the important relationships between sleep, mGlu receptors, and CNS disorders, this chapter highlights the development of selective mGlu receptor ligands that hold promise for improving both primary symptoms and sleep disturbances.
Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
Source : https://www.frontiersin.org/articles/10.3389/fmed.2022.984227/full
Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the...
Conclusions: Dual orexin receptor antagonist (DORA) can not only treat the sleep-wakefulness disorder of AD but also improve the performance of patients with cognitive behavior disorder. It is critical to clarify the role of the orexin system in AD, study its relationship with cognitive decline in AD, and evaluate the safety and efficacy of...
The effect of COVID-19 restrictions on sleep quality of university students and variables predicting sleep quality - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36824086/
Events related to the COVID-19 pandemic are associated with reduced sleep quality in connection with increasing negative moods. Considering the importance of sleep for a healthy life, efforts should be...
Conclusions: Events related to the COVID-19 pandemic are associated with reduced sleep quality in connection with increasing negative moods. Considering the importance of sleep for a healthy life, efforts should be made to raise awareness about this issue and to provide psychological help to affected individuals.
Regulated assembly and neurosteroid modulation constrain GABA A receptor pharmacology in vivo - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36824901/
Type A GABA receptors (GABA A Rs) are the principal inhibitory receptors in the brain and the target of a wide range of clinical agents, including anesthetics, sedatives, hypnotics, and...
Conclusions: Together, our data reveal that GABA A R assembly is a strictly regulated process that yields a small number of structurally distinct complexes, defining a structural landscape from which subtype-specific drugs can be developed.
The Metabolism of the Dual Orexin Receptor Antagonist Daridorexant - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36809238/
Daridorexant is a dual orexin receptor antagonist developed for the treatment of insomnia disorder and has shown improvement in sleep outcomes and daytime functioning. The present work describes its biotransformation...
Conclusions: Daridorexant is a dual orexin receptor antagonist developed for the treatment of insomnia disorder and has shown improvement in sleep outcomes and daytime functioning. The present work describes its biotransformation pathways in vitro and in vivo and provides a cross-species comparison between the animal species used in...