Daridorexant: First Approval - Drugs
Source : https://link.springer.com/article/10.1007/s40265-022-01699-y
Daridorexant (Quviviq™; Idorsia Pharmaceuticals Ltd.) is an orally administered dual orexin type 1 and type 2 (OX1 and OX2) receptor antagonist (DORA) being developed for the treatment of insomnia. It...
Conclusion: This article summarizes the milestones in the development of daridorexant leading to this first approval.
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Sleep Disorder Connect4yrKey Points • Source: AdisInsight • Relevance: “Based on the results of two pivotal phase III trials, daridorexant was recently approved in the USA for the treatment of adult patients with insomnia Show More
Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35587996/
1 Yunnan Engineering Research Center of Fruit Wine, QuJing Normal University, QuJing, People's Republic of China. 2 Yunnan University of Business Management, Kunming, People's Republic of China. 3 State Key...
Conclusion: Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism
A Systematic Review of the Impact of Select Mindfulness Interventions on Psychological Outcomes among Older Adults with Chronic Health Conditions - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35585039/
doi: 10.1080/07317115.2022.2076636. Online ahead of print. 1 School of Social Work, University of Michigan, Ann Arbor, Michigan, USA. 2 Department of Developmental Psychology, University of Michigan, Ann Arbor, Michigan, USA....
Clinical implications: Practitioners should be guardedly optimistic about the value of MIs and ACT for older adults with chronic health conditions.
Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study - Neuropsychopharmacology
Source : https://www.nature.com/articles/s41386-022-01319-z
Insomnia and restless leg syndrome (RLS) are associated with increased risk for suicidal behavior (SB), which is often comorbid with mood or thought disorders; however, it is unclear whether these...
Conclusion: Human genetic evidence supports for the first time a potentially independent and causal effect of insomnia on SB and encourages further clinical investigation of treatment of insomnia for prevention or treatment of SB.
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Sleep Disorder Connect4yrKey Points • Source: Neuropsychopharmacology • Conclusion: “Human genetic evidence supports for the first time a potentially independent and causal effect of insomnia on SB [suicidal behavior] and encourages further clinical investigation of treatment Show More
Misdiagnosis of narcolepsy caused by a false positive orexin-A/hypocretin-1 enzyme immune assay - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35481446/
The diagnosis of narcolepsy is based on clinical history, sleep studies, and, in some cases, cerebrospinal fluid orexin-A/hypocretin-1 measurement. The gold standard for orexin measurement is the radioimmune assay (RIA),...
Conclusion/Relevance: We report four cases where orexin levels were measured by EIA and resulted in false positives and the misdiagnosis of narcolepsy. Therefore, orexin EIA measurement should be strongly discouraged in a clinical setting.