Hypocretin-1 measurements in cerebrospinal fluid using radioimmunoassay: within and between assay reliability and limit of quantification
Source : https://academic.oup.com/sleep/advance-article/doi/10.1093/sleep/zsac103/6581446?login=false
AbstractStudy objectives. The most sensitive and specific investigative method for the diagnosis of narcolepsy type 1 (NT1) is the determination of hypocretin-1
Conclusions: Hypocretin-1 RIAs should always be harmonized using standard reference material. The specific activity of an RIA has a significant impact on its reliability, because of the decay of 125I radioactivity. Values around the hypocretin-1 cutt-off can reliably be measured. Hypocretin-1 concentrations below 28 pg/mL should be reported as...
Cannabinoids, insomnia, and other sleep disorders - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35537535/
Sleep disturbances are often cited as a primary reason for medicinal cannabis use and there is increasing clinical interest in the therapeutic potential of cannabinoids in treating sleep disorders. Burgeoning...
Relevance: This critical review summarises the current evidence for the use of cannabinoids as a treatment for sleep disorders, and provides an overview of endocannabinoid modulation of sleep-wake cycles, and the sleep-modulating effects of plant-derived cannabinoids such as Δ⁹-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol...
Toxicological Characterization of GHB as a Performance-Enhancing Drug
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9058118/
Performance-enhancing drugs (PEDs) are represented by several compounds used to ameliorate the image, the appearance, or an athletic or non-athletic performance. Gamma-hydroxybutyrate (GHB) is an endogenous molecule first used as...
Relevance: Indeed, performance-enhancing and therapeutic effects of GHB, including sleep, vigilance, and mood enhancement, widely overlap. It has been commonly used by body builders (8–11) who acted as early adopters, enhancement drug use innovators, and anticipated an increase in lean muscle mass due to the GHB-induced release of GH
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Sleep Disorder Connect4yrKey Points • Source: Frontiers in Psychiatry • Conclusion/Relevance: “The aim of the present work is to provide a toxicological characterization of the use of GHB as a PED [performance-enhancing drug], including the scientific Show More
Associations of long-term exposure to ambient air pollution and road traffic noise with sleep health in UK Biobank - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35513113/
doi: 10.1016/j.jad.2022.04.136. Online ahead of print. 1 Ministry of Education Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College,...
Conclusions: Long-term ambient air pollution is associated with overall sleep health. Road traffic noise itself is weakly associated with overall sleep health.
The moderating role of trait and state mindfulness between daily sleep and physical pain symptoms: an ecological momentary assessment and actigraphy study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35510694/
Objective: Poorer sleep quality and insufficient sleep increase the risk of physical pain. The current study examined the daily associations between sleep and physical pain symptoms and tested the moderating...
Conclusion: Even without mindfulness training, one's mindfulness may be protective against the adverse effects of poor sleep quality on physical pain.