Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
Source : https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)00878-9/fulltext
Overall, eszopiclone and lemborexant had a favorable profile, but eszopiclone might cause substantial adverse events and safety data on lemborexant were inconclusive. Doxepin, seltorexant, and zaleplon were well tolerated, but...
Interpretation: Overall, eszopiclone and lemborexant had a favorable profile, but eszopiclone might cause substantial adverse events and safety data on lemborexant were inconclusive. Doxepin, seltorexant, and zaleplon were well tolerated, but data on efficacy and other important outcomes were scarce and do not allow firm conclusions. Many...
Acute sodium oxybate intoxication: a case report and review of the literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35914751/
doi: 10.1097/FTD.0000000000001011. Online ahead of print. 1 Service de Pharmacologie-Toxicologie Pharmacovigilance, CHU Angers, Angers, France. 2 Université d'Angers. 3 Laboratoire MitoVasc, UMR INSERM 1083 CNRS 6015. 4 Service de Médecine...
Conclusion: In the present case, the estimated elimination half-life was 154 min. The risk of acute poisoning appears to be high considering the pharmacokinetic properties of sodium oxybate. Physicians and toxicologists must take such properties into account.
Asthma control, social jetlag, and sleep impairment in high school adolescents
Source : https://www.sciencedirect.com/science/article/abs/pii/S1389945722010760?via=ihub
Both controlled and uncontrolled asthma are associated with poor sleep and EDS in urban high school adolescents. * The present results provide no evidence of an association between social jetlag...
Conclusions: Asthma is associated with EDS and poor-quality sleep in adolescents. Social jetlag is common in these subjects and is not related to the presence and control of asthma.
Sodium Oxybate
Source : https://www.ncbi.nlm.nih.gov/books/NBK562283/
Sodium oxybate is a medication used to manage and treat narcolepsy with cataplexy or excessive daytime sleepiness. It is a Central Nervous System (CNS) depressant class of drugs.
Relevance: Sodium oxybate is a medication used to manage and treat narcolepsy with cataplexy or excessive daytime sleepiness. It is a Central Nervous System (CNS) depressant class of drugs. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, monitoring, relevant...
Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence, Severity, and Treatment Response - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35887329/
Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence,...
Conclusion: The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke.