The Orexin receptors: Structural and anti-tumoral properties
Source : https://www.frontiersin.org/articles/10.3389/fendo.2022.931970/full
At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were discovered. These two neuropeptides interacted with two G protein-coupled...
Conclusion: At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were discovered. These two neuropeptides interacted with two G protein-coupled receptor isoforms named OX1R and OX2R. The orexins/OX receptors system play an important role...
Network Analysis of Comorbid Anxiety and Insomnia Among Clinicians wit | NSS
DOI https://doi.org/10.2147/NSS.S367974 Checked for plagiarism Yes Peer reviewer comments 3 Depressive, anxiety and insomnia symptoms were common among clinicians during the Coronavirus disease (COVID-19) pandemic in many countries including China....
Conclusion: Central symptoms and key bridge symptoms identified in this NA should be targeted in the treatment and preventive measures for clinicians suffering from comorbid anxiety, insomnia and depressive symptoms during the late stage of the COVID-19 pandemic.
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Sleep Disorder Connect4yrKey Points • Source: Nature and Science of Sleep • Conclusion: “Central symptoms and key bridge symptoms identified in this NA [network analysis] should be targeted in the treatment and preventive measures for clinicians Show More
Orexin/hypocretin and major psychiatric disorders
Source : https://www.sciencedirect.com/science/article/abs/pii/S0065242322000312?via=ihub
Orexin A and B, also known as hypocretin 1 and 2, are excitory neuropeptides synthesized in the perifornical and lateral hypothalamic areas. Following their discovery in 1998, orexins are now...
Conclusion/Relevance: In this article, we aim to review studies of the orexin system associated with the three major psychiatric disorders: schizophrenia, major depressive disorder (MDD), and bipolar disorder. In addition to animal and clinical reports, studies of the orexin system in treatment, symptoms and side effects would also be reviewed.
Association Between Computer Vision Syndrome, Insomnia, and Migraine Among Lebanese Adults: The Mediating Effect of Stress
ABSTRACT Objective: Computer vision syndrome (CVS) refers to a group of ocular and extraocular symptoms due to prolonged digital device screen use. The objective of this study was to assess...
Conclusion: CVS was significantly associated with insomnia and migraine. Stress mediated the relationship between CVS and insomnia, and between CVS and migraine. The precise mechanisms behind these associations were not evaluated in this study, with the hope that future research will provide more information on this topic.
OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271901
Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy. Orexins act...
Relevance: Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy.