1yr
Disease Spotlight
Agitation in Alzheimer's Dementia
1yr
A Review of Recent Advances in the Management of Alzheimer's Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38756263/
Alzheimer's disease (AD) is the most common neurodegenerative condition and a form of dementia encountered in medical practice. Despite many proposed and attempted treatments, this disease remains a major puzzle...
This article reviews Alzheimer's disease treatments, covering mechanisms of neuronal damage, conventional therapies (cholinesterase inhibitors, monoclonal antibodies), innovative agents, anti-inflammatory drugs, and symptom-targeting medications, highlighting future combination therapies.
1yr
Circulating arginine metabolites in Alzheimer's disease and vascular dementia: A systematic review and meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38007048/
Alterations in ADMA, SDMA, and citrulline, biomarkers of NO synthesis, may be useful to investigate the pathophysiology of different forms of dementia and identify novel therapeutic strategies. (PROSPERO registration number:...
Alterations in ADMA, SDMA, and citrulline, key biomarkers of nitric oxide synthesis, may provide insights into dementia's pathophysiology and help identify new therapeutic approaches for Alzheimer's disease and vascular dementia.
1yr
Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer's disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38570083/
Here, we provide an in-depth consideration of our current understanding of engrams, spanning from molecular to network levels, and hippocampal neurogenesis, in health and Alzheimer's disease (AD). This review highlights...
This review explores the integration of engrams, episodic memory, and hippocampal neurogenesis in health and Alzheimer's disease, highlighting novel findings and future research directions for therapeutic approaches to memory failure.
1yr
Adherence to Online Interventions for Family Caregivers of People With Dementia: A Meta-Analysis and Systematic Review
Source : https://pubmed.ncbi.nlm.nih.gov/38735829/
Findings support the effectiveness of social support, personalization strategies, and co-design in enhancing intervention adherence among dementia family caregivers. Further research is needed to explore factors influencing dropout rates and...
The study highlights that social support, personalization, and co-design improve adherence in online interventions for dementia caregivers. Further research should explore factors influencing dropout and refine future intervention strategies.