Disease Spotlight
Agitation in Alzheimer's Dementia

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The role and mechanism of dapagliflozin in Alzheimer disease: A review - PubMed

The role and mechanism of dapagliflozin in Alzheimer disease: A review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39331931/

Alzheimer disease (AD), as the main type of dementia, is primarily characterized by cognitive dysfunction across multiple domains. Current drugs for AD have not achieved the desired clinical efficacy due...

SGLT-2 inhibitors show promise as potential treatments for Alzheimer's disease due to their neuroprotective effects, including antioxidative, anti-inflammatory, and antiapoptotic properties, alongside enhancing autophagy and protecting endothelial cells.

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Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia - PubMed

Dysregulation of Ion Channels and Transporters and Blood-Brain Barrier Dysfunction in Alzheimer's Disease and Vascular Dementia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38300642/

The blood-brain barrier (BBB) plays a critical role in maintaining ion and fluid homeostasis, essential for brain metabolism and neuronal function. Regulation of nutrient, water, and ion transport across the...

This review highlights the critical role of ion transporters at the blood-brain barrier, their dysregulation in neurodegenerative diseases like Alzheimer's, and the need for further research on their impact.

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Did you know?  Primary care settings that use behavioral health consultants can see up to a 50% improvement in treatment adherence among patients with chronic illnesses. Integrating mental health professionals into primary care teams helps address the psychological barriers to managing chronic conditions, such as diabetes or hypertension, enhancing overall patient outcomes.

Could the addition of behavioral health consultants in primary care be the key to overcoming adherence issues in managing chronic diseases?

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Could the addition of behavioral health consultants in primary care be the key to overcoming adherence issues in managing chronic diseases?

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Induced pluripotent stem cell models as a tool to investigate and test fluid biomarkers in Alzheimer's disease and frontotemporal dementia - PubMed

Induced pluripotent stem cell models as a tool to investigate and test fluid biomarkers in Alzheimer's disease and frontotemporal dementia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38246596/

Neurodegenerative diseases are increasing in prevalence and comprise a large socioeconomic burden on patients and their caretakers. The need for effective therapies and avenues for disease prevention and monitoring is...

Fluid biomarkers play an increasing role in neurodegenerative disease diagnosis and therapy monitoring, with iPSC models offering innovative approaches for biomarker discovery, high-throughput screening, and experimental therapeutics testing.

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Psilocybin for the treatment of Alzheimer's disease

Psilocybin for the treatment of Alzheimer's disease

Source : https://pubmed.ncbi.nlm.nih.gov/39050672/

Alzheimer's disease (AD) stands as a formidable neurodegenerative ailment and a prominent contributor to dementia. The scarcity of available therapies for AD accentuates the exigency for innovative treatment modalities. Psilocybin,...

Psilocybin presents a promising therapeutic potential for Alzheimer's disease by enhancing neural plasticity, reducing inflammation, and improving cognitive functions, warranting further research despite ethical and legal challenges.