Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy
Narcolepsy is a sleep disorder caused by loss of hypothalamic orexin neurons. An important feature of narcolepsy is episodes of muscle atonia during wakefulness, called cataplexy. Pintwala et al. show...
Conclusions/Relevance: We suggest that orexin signaling is critical for arousal-motor synchrony during wakefulness and that the dorsal raphe plays a pivotal role in coupling arousal and motor behaviors.
Design and Synthesis of Orexin 1 Receptor-Selective Agonists - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37043436/
Orexins are a family of neuropeptides that regulate various physiological events, such as sleep/wakefulness as well as emotional and feeding behavior, and that act on two G-protein-coupled receptors, i.e., orexin...
Conclusions/Relevance: The OX1R-selective agonist (R)-YNT-3708 exhibited antinociceptive and reinforcing effects through the activation of OX1R in mice.
Elusive hypersomnolence in seasonal affective disorder: actigraphic and self-reported sleep in and out of depressive episodes | Psychological Medicine | Cambridge Core
Elusive hypersomnolence in seasonal affective disorder: actigraphic and self-reported sleep in and out of depressive episodes - Volume 53 Issue 4
Conclusion: Despite a winter increase in total sleep time and year-round elevated daytime sleepiness, the average total sleep time (7 h) suggest hypersomnolence is a poor characterization of SAD. Importantly, self-reported hypersomnia captures multiple sleep disruptions, not solely lengthened sleep duration. We recommend using a...
Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings
Source : https://www.sciencedirect.com/science/article/pii/S2451994423000068?via=ihub
Prevalent chronotypes in Parkinson's disease are late morning and intermediate. * Patients with a blunted circadian activity had worse motor and cognitive profiles. * Circadian gene expression in Parkinson fibroblasts...
Conclusions/Relevance: This study contributes to the growing literature on CR abnormalities in the pathophysiology of Parkinson's disease providing a link between the clinical and biological patient chronotype and the disease phenomenology.
Associations between excessive fatigue and pain, sleep, mental-health and work factors in Norwegian nurses
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0282734
Aim To investigate whether pain, sleep duration, insomnia, sleepiness, work-related factors, anxiety, and depression associate with excessive fatigue in nurses. Background Fatigue among nurses is a problem in the context...
Conclusions: Excessive fatigue was associated with pain, sleep- and mental health-factors in a fully adjusted model.