The ABC's of Alzheimer Risk Gene ABCA7
Source : https://pubmed.ncbi.nlm.nih.gov/38556850/
Alzheimer's disease (AD) is a growing problem worldwide. Since ABCA7's identification as a risk gene, it has been extensively researched for its role in the disease. We review its recently...
Alzheimer's risk-increasing variants in ABCA7 can be found in up to 7% of individuals with Alzheimer disease.
Histories of Neighborhood Socioeconomic Status Contribute to Race Differences in Later-Life Cognition
Source : https://pubmed.ncbi.nlm.nih.gov/38552138/
Race is implicated in the likelihood of living in more disadvantaged neighborhoods. Historical trends in neighborhood disadvantage are associated with cognitive function in older adulthood. Identifying patterns of neighborhood change...
Race is implicated in the likelihood of living in more disadvantaged neighborhoods. Historical trends in neighborhood disadvantage are associated with cognitive function in older adulthood.
Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease
Source : https://www.eurekaselect.com/article/139353
Acetylcholine (ACh) is ubiquitously present in the nervous system and has been involved in the regulation of various brain functions. By modulating synaptic transmission and promoting synaptic plasticity, particularly in...
Identification of specific subtypes of cholinergic receptors involved in the pathogenesis of Alzheimer disease is essential to develop future drugs.
Healthier lifestyle was associated with better cognitive function proximate to death independently of Alzheimer disease pathology burden.
Self-Reported Late-Life Hypertension Is Associated With a Healthy Cognitive Status and Reduced Alzheimer's Disease Pathology Burden
Source : https://pubmed.ncbi.nlm.nih.gov/38552117/
Our findings suggest that late-life hypertension is associated with less severe AD pathology. We postulate that AD pathology may be promoted by reduced cerebral blood flow.
Late-life hypertension is associated with less-severe pathology, potentially promoted by reduced cerebral blood flow.