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Precision Medicine for Idiopathic Hypersomnia - PubMed

Precision Medicine for Idiopathic Hypersomnia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36150801/

Idiopathic hypersomnia (IH) includes a clinical phenotype resembling narcolepsy (with repeated, short restorative naps), and a phenotype with an excess of sleep, sleep drunkenness, drowsiness, and infrequent long, nonrestorative naps. Sleep tests reflect this heterogeneity. MSLTs are greater than 8 ...


Conclusions: Possible mechanisms of IH include deficiencies in arousal systems, inappropriate stimulation of sleep-inducing systems, and long biological night. Treatments now include robust studies of modafinil, clarithromycin, and sodium oxybate.