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Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases | Martinez-Orozco | Journal of Clinical Medicine Research

Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases | Martinez-Orozco | Journal of Clinical Medicine Research

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https://www.jocmr.org/index.php/JOCMR/article/view/4758

Francisco J. Martinez-Orozco, Miguel Fernandez-Arquero, Jose L. Vicario, Laura Lillo-Triguero, Elena Ameyugo, Rosa Peraita-Adrados Abstract Background: The aim of this study was to evaluate the long-term outcome of our series of narcolepsy type 1 (NT1) patients with comorbid autoimmune diseases (ADs) and other immunopathological diseases (IDs), focusing on the incidence of new ADs and IDs in this sample.


Conclusions: The prevalence of AD/ID is high in our series, suggesting that NT1 might arise on a background of generalized susceptibility to immune-mediated processes. The occurrence of an ID can in turn influence the development of others in genetically predisposed individuals, which explains the increased associations observed in this long-term study.