Solriamfetol treatment outcomes were analyzed according to depression history. * Depression history was prevalent in people with narcolepsy/obstructive sleep apnea. * Solriamfetol improved excessive daytime sleepiness regardless of depression history. * Concomitant antidepressant use did not affect response to solriamfetol. * Safety/tolerability was similar regardless of depression history/antidepressant use.
Conclusions: Civilian sleep specialists were twice as likely to diagnose central disorders of hypersomnolence compared to military specialists. Raising awareness about this discrepancy is critical given the occupational and patient care-related implications of misdiagnoses.