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Excessive Daytime Sleepiness in Japanese-American Male

History of Present Illness
Patient is a 22-year-old Asian-American male born in the U.S. Patient presents with symptoms ..... see more

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  • from Pulmonologist Connect 1 month
    Narcolepsy would be on top of my differential. Start with a PSG and MSLT
  • from Doctor Unite 1 month 2 weeks
    Age and symptoms could indicate narcolepsy , I would ask about cataplexy, hypnagogic hallucinations and sleep paralysis .i Would get a sleep study and consider provigil.
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Effects of vertical gastrectomy on sleep quality, eating behavior, and metabolic parameters in obese adults: a case study

ABSTRACT Obesity is a serious, chronic, and progressive disease associated with physiological dysfunctions that interact with circadian clock activity. Vertical gastrectomy (VG) is currently the most frequently performed bariatric procedure ..... see more

Source : https://www.tandfonline.com/doi/abs/10.1080/09291016.2021.1906504?journalCode=nbrr20&

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Narcolepsy and psychosis: a systematic review - PubMed

Epidemiological studies tentatively suggest a possible association between narcolepsy and schizophrenia only for very early-onset cases, which could be related to the partially overlapping neurodevelopmental changes observed in these disorders. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33779983/

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What Is Wrong with My Child? Narcolepsy and Its Emotional Burden on Parents

Anna Wani Rachel Rosen S. Kamal Naqvi Narcolepsy is a lifelong disorder that is underdiagnosed and misunderstood. It is typically years before a proper diagnosis is made. During this time, ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-59309-4_10

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Different positron emission tomography findings in schizophrenia and narcolepsy type 1 in adolescents and young adults: a preliminary study - PubMed

1 Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan. 2 Department of Medical Imaging and Radiological Sciences, College ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33226331/

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Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype

Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood. Recent studies demonstrated that NT1 presents with age-specific features, especially in children. With this ..... see more

Source : https://jcsm.aasm.org/doi/abs/10.5664/jcsm.9198

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Does Homeostatic Sleep Pressure Buildup Explain Objective Excessive Daytime Sleepiness in Adults With ADHD? An Exploratory Study

Background: Excessive daytime sleepiness (EDS) is central in Attention deficit hyperactivity disorder (ADHD) but its causes remain unclear. see more

Source : https://www.frontiersin.org/articles/10.3389/fpsyt.2021.586528/full

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Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type 1

Abstract. The hypocretin/orexin system regulates arousal through central nervous system mechanisms and plays an important role in sleep, wakefulness, and energy see more

Source : https://doi.org/10.1093/braincomms/fcab050

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High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1

AbstractStudy objectives. Narcolepsy type 1 (NT1) is associated with hypocretin neuron loss. However, there are still unexplained phenotypic NT1 features. We in see more

Source : https://academic.oup.com/sleep/advance-article/doi/10.1093/sleep/zsab062/6168886?login=true

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Recognizing and Treating Excessive Daytime Sleepiness in Patients With Narcolepsy | Psychiatrist.com

Article AbstractSleep disorders such as narcolepsy can cause excessive daytime sleepiness (EDS). The diagnosis of narcolepsy is often delayed by years. Clinicians can improve the recognition of EDS and diagnosis ..... see more

Source : https://www.psychiatrist.com/jcp/psychiatry/recognizing-and-treating-eds-in-patients-with-narcolepsy/

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Two sides of a coin: differential response to COVID-19 distancing measures in children with narcolepsy.

Narcolepsy is a chronic neurological sleep disorder, debuting before the age of fifteen in one-third of the cases. Narcolepsy has a negative influence on quality of life, with daily functioning ..... see more

Source : https://doi.org/10.5664/jcsm.9040

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A novel parameter is better than the AHI to assess nocturnal hypoxaemia and excessive daytime sleepiness in obstructive sleep apnoea

To evaluate whether the percentage of total sleep time spent with apnoea and hypopnoea duration time (AHT%) is better than the apnoea-hypopnoea index (AHI) for the assessment of nocturnal hypoxaemia ..... see more

Source : https://www.nature.com/articles/s41598-021-84239-0

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Narcolepsy type 1 features across the life span: age impact on clinical and polysomnographic phenotype

Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood. Recent studies demonstrated that NT1 presents with age-specific features, especially in children. With this ..... see more

Source : https://jcsm.aasm.org/doi/abs/10.5664/jcsm.9198

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Regional brain metabolism differentiates narcolepsy type 1 and idiopathic hypersomnia

AbstractStudy Objectives. Daytime sleepiness is a manifestation of multiple sleep and neurologic disorders. Few studies have assessed patterns of regional brain see more

Source : https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsab050/6161267

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Dissociative Symptoms are Highly Prevalent in Adults with Narcolepsy Type 1

Introduction: The core symptoms of narcolepsy such as excessive daytime sleepiness and cataplexy are well known. However, there is mounting evidence for a much broader symptom spectrum, including psychiatric symptoms. ..... see more

Source : https://doi.org/10.1080/15402002.2021.1888729

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Hypothalamic MCH Neuron Activity Dynamics during Cataplexy of Narcolepsy - PubMed

1 Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425. 2 Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425 ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32303567/

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Therapy for Cataplexy

Purpose of the review Cataplexy, an involuntary loss of muscle activity triggered by strong emotions is the most impressive symptom in narcolepsy. This review gives an overview of the current ..... see more

Source : https://link.springer.com/article/10.1007/s11940-020-0619-5

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Narcolepsy with cataplexy: Does age at diagnosis change the clinical picture?

Patricia Franco Corresponding Author Integrative Physiology of the Brain Arousal Systems, CRNL, INSERM‐U1028, CNRS UMR5292, University of Lyon 1, Lyon, France Sleep Pediatric Unit, Woman Mother Child Hospital, Civil Hospices ..... see more

Source : https://onlinelibrary.wiley.com/doi/full/10.1111/cns.13438

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Localizing deficits in white matter tracts of patients with narcolepsy with cataplexy: tract-specific statistical analysis

White matter alterations related to hypocretin pathway have been less evaluated in patients who have narcolepsy with cataplexy (NC), as compared to the identified exploration of gray matter and have ..... see more

Source : https://link.springer.com/article/10.1007/s11682-019-00100-z