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Sara Bassler, Susan Balke from Doctor Unite Commented on a Post
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Excessive daytime sleepiness (EDS) is commonly associated with obstructive sleep apnea (OSA), which is the most common sleep disorder. EDS is a major facet of OSA that can persist despite patients receiving adequate treatment for their OSA. Currently available treatments for OSA, including continuous positive airway pressure (CPAP) and oral appliances, are often underused or rejected by patients. There are several reasons for this such as insurance coverage, discomfort, inconvenience, as well as perceived efficacy. A review by Léger and Stepnowsky (2020) found demonstrated rates of EDS in OSA of 12%-65% using the most commonly reported definition of EDS (Epworth Sleepiness Scale ≥11), and a prevalence of persistent EDS in OSA following continuous positive airway pressure treatment of 12%-65%. EDS manifests in multiple ways with adverse behavioral health outcomes, such as the serious safety issue of falling asleep while driving. There is a 2-3-fold increase in risk for patients with OSA experiencing a driving accident. Thus, EDS in OSA has a significant negative impact on quality of life, increasing socio-economic burden and damaging public health. 
 

In your experience, what are the critical unmet needs associated with excessive daytime sleepiness and obstructive sleep apnea?

1. Leger, Damien, and Carl Stepnowsky. "The economic and societal burden of excessive daytime sleepiness in patients with obstructive sleep apnea." Sleep medicine reviews (2020): 101275.

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  • 1 day 13 hours
    I am a psychiatrist who was diagnosed with OSA and EDS while in my 50s. I've repeatedly been told that my CPAP is working perfectly and that my compliance Show More
  • from Doctor Unite 2 days 17 hours
    Getting approval (prior authorization) is the PITS!! Takes days, then appeals, often months go by til we can get the sleep study approved for suspected OSA....
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Sleep Problems in Narcolepsy and the Role of Hypocretin/Orexin Deficiency - PubMed

Since its description in the 19th century, narcolepsy type 1 (NT1) has been considered as a model sleep disorder, and after the discovery of rapid eye movement (REM) sleep onset ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34052809/

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Perampanel-Induced Cataplexy in a Young Male with Generalized Epilepsy | CNS Spectrums | Cambridge Core

Perampanel is an anti-epileptic drug reported to exert its effects in the central never system (CNS) by inhibiting post-synaptic glutamate receptors. The most commonly reported neuropsychiatric side effects are affective ..... see more

Source : https://www.cambridge.org/core/journals/cns-spectrums/article/perampanelinduced-cataplexy-in-a-young-male-with-generalized-epilepsy/3798B2E010B73B073991145D7C5EBFEC

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Symptom shift in 200 patients with H63D syndrome associated with abnormal TCS findings in substantia nigra

In a study on the prevention of injury in patients with H63D syndrome and cataplexy, statistical analysis revealed an unexpected but clinically highly significant finding. Apparently, in this patient population, ..... see more

Source : https://doi.org/10.21203/rs.3.rs-564544/v1

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Efficacy and Safety of Lower-Sodium Oxybate in a Phase 3, Placebo-Controlled, Double-Blind, Randomized Withdrawal Study in Adult Participants With Idiopathic Hypersomnia (2659)

Objective: Evaluate efficacy/safety of calcium, magnesium, potassium, and sodium oxybates (lower-sodium oxybate [LXB], Xywav™; previously designated JZP-258), a novel oxybate treatment with 92% less sodium than sodium oxybate (SXB; Xyrem®) ..... see more

Source : https://n.neurology.org/content/96/15_Supplement/2659.abstract

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Regularly missed symptoms in primary and secondary narcolepsy

Regularly missed symptoms in primary and secondary narcolepsy Dr. Carolina Diamandis , Jacob S Adams, Riku Honda, Marius Lazar, David Seideman Based on an analysis of anonymized medical records from ..... see more

Source : https://www.authorea.com/doi/full/10.22541/au.162134961.11409756

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Symptom shift in 200 patients with H63D syndrome associated with abnormal TCS findings in substantia nigra

Symptom shift in 200 patients with H63D syndrome associated with abnormal TCS findings in substantia nigra Dr. Carolina Diamandis , David Seideman, Jacob S Adams, Riku Honda, Marianne Kaufmann, Lucas ..... see more

Source : https://www.authorea.com/doi/full/10.22541/au.162207127.76269647

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Regional brain metabolism differs between narcolepsy type 1 and idiopathic hypersomnia

AbstractStudy Objectives. Daytime sleepiness is a manifestation of multiple sleep and neurologic disorders. Few studies have assessed patterns of regional brain see more

Source : https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsab050/6161267

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Risk of Excessive Daytime Sleepiness Associated to Major Depression in Adolescents

Given the limited data currently available in the literature, the aim of this study was to investigate the risk of excessive daytime sleepiness (EDS) associated with major depression in a ..... see more

Source : https://link.springer.com/article/10.1007/s11126-021-09922-x

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Perampanel-Induced Cataplexy in a Young Male with Generalized Epilepsy | CNS Spectrums | Cambridge Core

Perampanel is an anti-epileptic drug reported to exert its effects in the central never system (CNS) by inhibiting post-synaptic glutamate receptors. The most commonly reported neuropsychiatric side effects are affective ..... see more

Source : https://www.cambridge.org/core/journals/cns-spectrums/article/perampanelinduced-cataplexy-in-a-young-male-with-generalized-epilepsy/3798B2E010B73B073991145D7C5EBFEC

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Prevalence of narcolepsy in patients with H63D syndrome

H63D syndrome is a phenotype of a homozygous mutation of the HFE gene H63D, which is otherwise known to cause at most mild classical hemochromatosis. H63D syndrome leads to an ..... see more

Source : https://www.authorea.com/doi/full/10.22541/au.162066496.69113793

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Abnormally abrupt transitions from sleep-to-wake in Huntington's disease sheep (Ovis aries) are revealed by automated analysis of sleep/wake transition dynamics

Sleep disturbance is a common and disruptive symptom of neurodegenerative diseases such as Alzheimer's and Huntington's disease (HD). In HD patients, sleep fragmentation appears at an early stage of disease, ..... see more

Source : https://doi.org/10.1371/journal.pone.0251767

56-year-old patient with history of PTSD

A fifty-six-year-old male presents with history of post-traumatic stress disorder due to childhood physical abuse. He has trouble sleeping due to ..... see more

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  • from Doctor Unite 4 weeks
    You could use a sleep aid such as gaba or trazodone as well
  • from Doctor Unite 4 weeks
    I am a big advocate for therapy for this patient given his problems from his past.
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Type 1 narcolepsy without cataplexy and treatment progress: a case report

Narcolepsy is a sleep disorder with the main manifestations of excessive daytime sleepiness, cataplexy, sleep paralysis, sleep hallucinations, and nighttime sleep disturbance. It is the most common disease that causes ..... see more

Source : https://apm.amegroups.com/article/view/66083/html

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CAT-CAD: A Computer-Aided Diagnosis Tool for Cataplexy

Narcolepsy with cataplexy is a severe lifelong disorder characterized, among others, by sudden loss of bilateral face muscle tone triggered by emotions (cataplexy). A recent approach for the diagnosis of ..... see more

Source : https://www.mdpi.com/2073-431X/10/4/51