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Emad Bishai, Jorge Osorio from Doctor Unite Commented on a Post
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Next-day impacts of insomnia

Insufficient sleep has been associated with difficulty focusing, impaired memory, impaired decision-making, and slower reaction times. This underscores the importance of treating and managing insomnia for employability, safety, and quality of life. According to the DSM-5, the diagnosis of insomnia is based not only on nighttime sleep issues but also daytime impairment that can impact a patient’s academic, social or work life. In a recent study, 73% of insomnia patients complained of challenges falling asleep, and 84% experienced issues with daily functioning.

In clinical trials, patients taking daridorexant (Quviviq) 50 mg reported improvements in daytime sleepiness versus placebo as measured by the Insomnia Daytime Symptoms and Impacts Questionnaire (IDSIQ). This improvement started 1 week after the initial administration and continued to improve over time. Statistically significant nighttime improvements versus placebo were also seen in falling asleep faster, staying asleep longer, and increased total time asleep. These results could be promising since many sleep medications are associated with next-day hangover effects.

Why do you think that patients taking daridorexant 50 mg showed a statistically significant reduction in daytime sleepiness vs placebo? What factors may be contributing to this finding?

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  • November 25, 2022
    Insomnia is associated with daytime sleepiness, fatigue and inability to focus, Also is associated with increased risk of MVA, especially for long distance drivers. There is increased symptoms of irritable mood Show More
  • from Doctor Unite November 07, 2022
    Patients showed improvement quality of life, better sleep with no significant side effects .
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SLeep Education for Everyone Program (SLEEP) Results in Sustained Improvements in Sleep Outcomes at Six Months - PubMed

doi: 10.1080/15402002.2022.2146693. Online ahead of print. 1 Office of Research and Education, Spectrum Health West Michigan, Grand Rapids, Michigan. 2 Michigan State University Extension. Michigan State University, East Lansing, Michigan. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36377788/


Conclusions: These results suggest that a community-delivered sleep education intervention can produce sustained benefits for participants and should be considered as a tool to address uncomplicated sleep issues.


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Understanding and approaching excessive daytime sleepiness

Excessive daytime sleepiness (EDS) is a public health issue. However, it remains largely undervalued, scarcely diagnosed, and poorly supported. Variations in the definition of EDS and limitations in clinical assessment ..... see more

Source : https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01018-2/fulltext


Conclusions: Because of the heterogeneous causes of EDS and the complexity of its pathophysiology, management will largely depend on the cause, with the final aim of making treatment specific to the individual using precision medicine and personalised medicine.


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The relationship between Alzheimer's-related brain atrophy patterns and sleep macro-architecture - PubMed

1 Department of Psychiatry and Psychotherapy University Medicine Greifswald Greifswald Mecklenburg-Vorpommern Germany. 2 German Centre for Neurodegenerative Diseases (DZNE) Site Rostock/Greifswald Greifswald Mecklenburg-Vorpommern Germany. 3 Department of Internal Medicine B-Cardiology ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36381559/


Discussion: There is a cross-sectional relationship between AD-related neurodegenerative patterns and the proportion of sleep spent in slow-wave sleep."


Efficacy and Safety of Lower-Sodium Oxybate in an Open-Label Titration | NSS

Idiopathic hypersomnia is a sleep disorder that causes daytime sleepiness. Many patients also have difficulty awakening, long sleep time at night, long and unrefreshing naps, and problems thinking clearly. Lower-sodium ..... see more

Source : https://www.dovepress.com/efficacy-and-safety-of-lower-sodium-oxybate-in-an-open-label-titration-peer-reviewed-fulltext-article-NSS


Conclusions: During open-label treatment with LXB, participants showed clinically meaningful improvements in idiopathic hypersomnia symptoms and in quality of life and functional measures. TEAE incidence declined over LXB titration and optimization.

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  • November 14, 2022
    Key Points • Source: Nature and Science of Sleep • Relevance: “These results show that lower-sodium oxybate improved symptoms of idiopathic hypersomnia and improved participants’ quality of life, day-to-day functioning, and ability to work. Show More

Evaluation of Sleep Habits and Disturbances Among US Adults, 2017-2020 - PubMed

In 2017 to 2020, US adults showed variability in sleep habits between workdays and free days, with longer sleep duration and later sleep-wake phases on free days, and high percentages ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36346632/


Meaning:These findings elaborate on sleep habits and disturbances among US adults and provide evidence to further investigate potential approaches to optimize overall US sleep health.

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  • November 14, 2022
    Key Points • Source: JAMA Network Open • Meaning: “These findings elaborate on sleep habits and disturbances among US adults and provide evidence to further investigate potential approaches to optimize overall US sleep health.” • In Show More
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Daridorexant, a recently approved Dual Orexin Receptor Antagonists (DORA) in the treatment of insomnia

Insomnia is one of the major challenges in medical science now a days as it leads to great socio-economic burden by impairing the daytime function as well as development of ..... see more

Source : https://www.eurekaselect.com/article/127449


Conclusions: Conclusions/Relevance: Beyond the effectiveness in insomnia, it has been successfully used in patients suffering from Obstructive sleep apnoea, Chronic Obstructive Airway Disease (COAD), Alzheimer’s Disease (AD), hypertension and cardiovascular disorders. Larger studies need to address the safety issues as well as obtaining...

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Central Disorders of Hypersomnolence: Association with Fatigue, Depression and Sleep Inertia Prevailing in Women - PubMed

1 Department of Neurology, Center of Clinical Neurosciences, General University Hospital, Charles University, Katerinska 30, 128 00 Prague, Czech Republic. 2 Unit of Statistics, Institute of Clinical and Experimental Medicine, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36358417/


Conclusions: Fatigue, depression, and sleep inertia are frequently underdiagnosed manifestations in narcolepsy and idiopathic hypersomnia. Our cross-sectional study design included diagnostic interview accompanied by assessment instruments and aimed to explore how these factors influence disease severity as well as to elucidate any sex...

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French Sleepiness Scale for Adolescents-8 items: A discriminant and diagnostic validation

In adolescents, excessive daytime sleepiness (EDS) is common and is associated with a decrease in academic achievement [1]. Insufficient duration of sleep is the main underlying cause of sleepiness at ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S0013700622001737?via=ihub

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Conclusions: "Conclusion: The FSSA8 appeared to be more reliable for patients than for nonclinical participants and to be a good tool for screening excessive daytime sleepiness in sleep disorders."

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Association of a History of Sleep Disorder With Risk of Mild Cognitive Impairment and Alzheimer's Disease Dementia

Choe, Suh, Kim, and Alzheimer's Disease Neuroimaging Initiative: Association of a History of Sleep Disorder With Risk of Mild Cognitive Impairment and Alzheimer's Disease Dementia Availability of Data and Material ..... see more

Source : https://www.psychiatryinvestigation.org/journal/view.php?doi=10.30773/pi.2022.0176

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Conclusions:"Our findings suggest that a sleep disorder history usefully aids early detection of cognitive impairment and emphasize that such sleep disorder, particularly OSA, is important as potential target for AD prevention."

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Efficacy and Safety of Lower-Sodium Oxybate in an Open-Label Titration | NSS

Idiopathic hypersomnia is a sleep disorder that causes daytime sleepiness. Many patients also have difficulty awakening, long sleep time at night, long and unrefreshing naps, and problems thinking clearly. Lower-sodium ..... see more

Source : https://www.dovepress.com/efficacy-and-safety-of-lower-sodium-oxybate-in-an-open-label-titration-peer-reviewed-fulltext-article-NSS


Conclusions: During open-label treatment with LXB, participants showed clinically meaningful improvements in idiopathic hypersomnia symptoms and in quality of life and functional measures. TEAE incidence declined over LXB titration and optimization.


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Planetary sleep medicine: Studying sleep at the individual, population, and planetary level

Circadian rhythms are a series of endogenous autonomous oscillators that are generated by the molecular circadian clock which coordinates and synchronizes internal time with the external environment in a 24-h ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fpubh.2022.1005100/full


Conclusions: The history of sleep and biological rhythms is the history of mankind and of the planet. Sleep (or sleep-like states), circadian (sleep-wake cycle), and other biological rhythms, have ancient phylogenetic roots, deeply permeating and orchestrating virtually all the ecosystems of the planet. Anthropogenic behaviors have been...

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French Sleepiness Scale for Adolescents-8 items: A discriminant and diagnostic validation

In adolescents, excessive daytime sleepiness (EDS) is common and is associated with a decrease in academic achievement [1]. Insufficient duration of sleep is the main underlying cause of sleepiness at ..... see more

Source : https://www.sciencedirect.com/science/article/abs/pii/S0013700622001737?via=ihub

/>

Conclusions: The FSSA8 appeared to be more reliable for patients than for nonclinical participants and to be a good tool for screening excessive daytime sleepiness in sleep disorders.

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Development and Initial Validation of the Assessment of Sleep Environment (ASE): Describing and Quantifying the Impact of Subjective Environmental Factors on Sleep - PubMed

The purpose of this study was to develop and test the reliability and validity of a 13-item self-report Assessment of Sleep Environment (ASE). This study investigates the relationship between subjective ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36294179/


Conclusions: The ASE is a reliable and valid measure of sleep environment. Physical environment (light, temperature, safety, noise, comfort, humidity, and smell) was associated with insomnia symptoms and sleep quality but not sleepiness.

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Clinical and neurophysiological characteristics of 89 patients with narcolepsy and cataplexy from the Russian Narcolepsy Network - PubMed

doi: 10.5664/jcsm.10340. Online ahead of print. 1 Sechenov University, Moscow, Russia. 2 Samara State Medical University, department neurology and neurosurgery, Samara, Russia. 3 Samara State Medical University, Research Institute of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36305577/


Conclusions: Clinical and neurophysiological data from this first study of the Russian Narcolepsy Network suggest a similar profile to the recently reported EU-NN data. The more severe and higher percentage of patients with cataplexy and presenting with both excessive daytime sleepiness (EDS) and cataplexy may reflect low awareness of...

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Precision Medicine for Idiopathic Hypersomnia - PubMed

Idiopathic hypersomnia (IH) includes a clinical phenotype resembling narcolepsy (with repeated, short restorative naps), and a phenotype with an excess of sleep, sleep drunkenness, drowsiness, and infrequent long, nonrestorative naps. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36150801/


Conclusions: Possible mechanisms of IH include deficiencies in arousal systems, inappropriate stimulation of sleep-inducing systems, and long biological night. Treatments now include robust studies of modafinil, clarithromycin, and sodium oxybate.


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Conclusion/Relevance: Higher fish consumption may be associated with a lower WBC count in the presence of adequate sleep duration and healthy lifestyle behaviors. However, long sleep duration was also related to increased inflammation, even in populations with high fish consumption. Further studies are needed to clarify the causality between...

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  • from Doctor Unite October 26, 2022
    Interesting article that explains -High fish consumption may be associated with lower inflammation, suppressing atherosclerotic cardiovascular disease (ASCVD)
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A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia - PubMed

Insomnia affects 4.4-4.8% of the world's population, but because the effect of hypnotic drugs is limited and may cause harmful side-effects, scientists are turning their attention to developing drugs that ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36144776/


Conclusion/Relevance: The use of daridorexant is considered safe, with no clinically significant side-effects including deprivation of next-morning residual effects. In this manuscript we conducted a comprehensive review of daridorexant including pharmacodynamics, animal and human research, pharmacokinetics and safety.

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Use of digital screens by adolescents and association on sleep quality: a systematic review

This study aimed to analyze the influence of digital screen use on adolescents' quality of sleep. This systematic review was recorded on PROSPERO (CRD42020203403) and conducted according to PRISMA guidelines. ..... see more

Source : https://www.scielo.br/j/csp/a/Zv7rmV5TVmRGkGWyrxWm4qd/?lang=en


Conclusion/Relevance: Excessive use of digital screens was associated with worse and shorter sleep, showing, as its main consequences, night awakenings, long sleep latency, and daytime sleepiness. The use of mobile phones before bedtime was associated with poor quality of sleep among adolescents. Our evaluation of the methodological quality...

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Conclusion: Compared to the current neurophysiological standard criteria, alternative MSLT parameters would better identify hypocretin-deficiency among patients with hypersomnolence and those with narcolepsy. We highlighted daytime REM sleep duration as a relevant neurophysiological biomarker of hypocretin-deficiency to be used in clinical...