
Patient Background:
A young adult patient with lifelong delayed sleep timing presented with difficulty initiating sleep until early morning hours and significant daytime impairment. The patient also had optic nerve hypoplasia (ONH), a developmental optic nerve condition associated with visual pathway abnormalities.
Family history was negative for delayed…read more
sleep disorders.
Assessment and Diagnosis:
Clinical evaluation confirmed delayed sleep-wake phase disorder (DSWPD). Actigraphy and sleep logs demonstrated a persistent delayed sleep phase.
Given the coexisting ONH and absence of identified circadian gene mutations, a circadian entrainment abnormality was suspected. Targeted circadian-based pharmacologic therapy was initiated, with improvement in sleep timing and daytime function.
- Please provide a minimum of a 3 sentence response.
- 1.In impaired light entrainment, how do you sequence light therapy and pharmacologic phase shifting?
- 2.When partial phase advancement occurs, when do you escalate or combine modalities?


