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PRIME PubMed | A unifying theory for the pathoetiologic mechanism of tardive dyskinesia

PRIME PubMed | A unifying theory for the pathoetiologic mechanism of tardive dyskinesia

Source : https://www.unboundmedicine.com/medline/citation/32200182/A_unifying_theory_for_the_pathoetiologic_mechanism_of_tardive_dyskinesia

Chronic treatment with dopamine D2 receptor antagonists has been proposed to lead to dopamine receptor supersensitivity. Frequently, this is conceptualized as upregulation or changes in the structure or function of the post-synaptic D2 receptor. However, the measured 1.4-fold increase in D2 receptor density and the lack of actual receptor supersensitivity are probably inadequate to explain outcomes such as tardive dyskinesia (TD) and dopamine supersensitivity psychosis.