Skip to main content
micro-community-banner
 
Profile Image
  • Saved

Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders

Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders

Source : https://www.nature.com/articles/s41598-020-65211-w

Modulation of subthalamic nucleus (STN) firing patterns with injections of depolarizing currents into the STN is an important advance for the treatment of hypokinetic movement disorders, especially Parkinson's disease (PD). .....

  • Saved

The role of glutamate receptors and their interactions with ... : Behavioural Pharmacology

The role of glutamate receptors and their interactions with ... : Behavioural Pharmacology

Source : https://journals.lww.com/behaviouralpharm/Abstract/9000/The_role_of_glutamate_receptors_and_their.99179.aspx

cal hypothesis of tardive dyskinesia development includes dopaminergic imbalance in the direct and indirect pathways of the basal ganglia, cholinergic deficiency, serotonin receptor disturbances, neurotoxicity, oxidative stress, and changes in .....

22 yo male with SchizoAffective Disorder, OCD, Tourettes treated with Abilify, Lithium, Prozac who now develops TD in leg with spasticity and pain. Taken off Abilify and Schizophrenia starting to .....

THOMAS VALENTE, Sunil Chauhan from Neurologist Connect Commented on a Post
  • Saved

Effectively treating both tardive dyskinesia and underlying psychiatric condition

Tardive Dyskinesia, or involuntary and uncontrolled movements in patients with psychiatric disorders, is not a symptom of underlying disease, but rather a side effect of their drug treatment, typically associated with antipsychotic therapies that inhibit dopamine receptors. As such, patients with psychotic disorders such as schizophrenia or bipolar disorder are commonly affected by TD, as well as those prescribed antipsychotics over a prolonged period for other conditions such as major depressive disorder.

In some cases, TD can cause functional impairment, interfering with a patient’s quality of life. It can be embarrassing, socially isolating, and can often add to the stigma related to their mental illness. Proper management of TD is therefore equally as important as managing the underlying psychiatric disorder, in order to provide the best treatment outcome possible. FDA-approved treatments for TD are available, allowing targeted improvement of involuntary movements while maintaining antipsychotic use. Lowering the antipsychotic dose may compromise the primary treatment goal and may result in a relapse with accompanying psychotic or depressive episode.

To what extent does a patient’s TD complicate their overall treatment? Knowing the potential functional, physical, and social stigma issues, how important would you consider managing TD for patient quality of life/outcomes?

  • Saved

I would like an Ingrezza representative to call on me, please: Arthur N Papas, MD 781-431-7399.
Thank you.

  • Saved

Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms

Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms

Source : https://link.springer.com/article/10.1007/s00213-020-05526-8

We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Protein-protein interaction (PPI) networks .....

  • Saved

Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms

Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms

Source : https://link.springer.com/article/10.1007/s00213-020-05526-8

We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Protein-protein interaction (PPI) networks .....

  • Saved

Parkinson's dyskinesia mechanism explained

Source : https://www.sciencedaily.com/releases/2020/05/200501150558.htm

Many people with Parkinson's disease eventually develop debilitating movements called dyskinesia, a side effect of their much-needed dopamine replacement medication. The mechanism underlying this unwanted side effect has been unknown, .....

  • Saved

RE-KINECT: A Prospective Study of the Presence and... : Journal of Clinical Psychopharmacology

RE-KINECT: A Prospective Study of the Presence and... : Journal of Clinical Psychopharmacology

Source : https://journals.lww.com/psychopharmacology/FullText/2020/05000/RE_KINECT__A_Prospective_Study_of_the_Presence_and.7.aspx

disorder. Based on clinician observation and assessment, patients were assigned to cohort 1 (without involuntary movements or with non-TD involuntary movements) or cohort 2 (with involuntary movements confirmed by clinician .....

  • Saved

Use of Valbenazine in a 54-Year-Old Female with Severe Tardive Dyskinesia

Use of Valbenazine in a 54-Year-Old Female with Severe Tardive Dyskinesia

Source : https://www.cureus.com/articles/25784-use-of-valbenazine-in-a-54-year-old-female-with-severe-tardive-dyskinesia

Tardive dyskinesia (TD) is a serious and often irreversible involuntary muscle movement that involves the face, lips, tongue, trunk, and extremities. TD is a risk in the use of antipsychotic .....

  • Saved

International Journal of Medical Reviews and Case Reports

International Journal of Medical Reviews and Case Reports

Source : https://mdpub.net/?mno=29208

Abstract Aim of study: The aim of our study is to investigate the role of the age, gravida, parity, blood group in the development of GTD also significance of the .....

  • Saved

Dystonia

Dystonia

Source : https://link.springer.com/chapter/10.1007/978-3-030-36346-8_14

Maria Fiorella Contarino Joachim K. Krauss Dystonic syndromes can be complex and present with different characteristics. Both accurate clinical diagnosis and characterization of dystonia can be very challenging and require .....

  • Saved

The Effects of the Rome IV Criteria on Pediatric Gastrointestinal Practice

The Effects of the Rome IV Criteria on Pediatric Gastrointestinal Practice

Source : https://link.springer.com/article/10.1007/s11894-020-00760-8

To evaluate the impact of the implementation of the Rome IV criteria on pediatric gastrointestinal practice. In 2016, the Rome IV criteria were published, providing an update of symptom-based criteria .....

  • Saved

A CASE OF TARDIVE DYSKINESIA (TD) IN A PATIENT WITH NON SQUAMOUS CELL CARCINOMA BEING TREATED WITH ARIPIPRAZOLE

A CASE OF TARDIVE DYSKINESIA (TD) IN A PATIENT WITH NON SQUAMOUS CELL CARCINOMA BEING TREATED WITH ARIPIPRAZOLE

Source : https://www.researchgate.net/publication/339920864_A_CASE_OF_TARDIVE_DYSKINESIA_TD_IN_A_PATIENT_WITH_NON_SQUAMOUS_CELL_CARCINOMA_BEING_TREATED_WITH_ARIPIPRAZOLE

Download Citation | A CASE OF TARDIVE DYSKINESIA (TD) IN A PATIENT WITH NON SQUAMOUS CELL CARCINOMA BEING TREATED WITH ARIPIPRAZOLE | Introduction Aripiprazole is an atypical antipsychotic that is .....

  • Saved

Case report of first-episode psychotic symptoms in a patient with early-onset Alzheimer's disease

Case report of first-episode psychotic symptoms in a patient with early-onset Alzheimer's disease

Source : https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02537-9

Alzheimer's disease (AD) is a neurodegenerative disorder featuring the behavioral and psychological symptoms of dementia. Patients with early-onset AD that exhibits first as psychotic symptoms usually lack obvious cognitive impairment, .....

  • Saved

Treatment of tics associated with Tourette syndrome

Treatment of tics associated with Tourette syndrome

Source : https://link.springer.com/article/10.1007/s00702-019-02105-w

Motor and phonic tics associated with Tourette syndrome (TS) can range in severity from barely perceptible to disabling and most patients have a variety of behavioral co-morbidities, particularly, attention deficit .....

  • Saved

The Management of Dementia

Source : https://www.enetmd.com/content/management-dementia

The management of dementia Topics covered: Introduction Assessment Screening for dementia History and examination Screening assessments and investigations Communication and consent Cognitive symptoms Psychological techniques Elderly people Younger people with .....

  • Saved

Psychopharmacotherapy in Patients with Tics and Other Motor Disorders

Psychopharmacotherapy in Patients with Tics and Other Motor Disorders

Source : https://link.springer.com/referenceworkentry/10.1007/978-3-319-56015-1_257-1

Yijing Bai Long Niu Song Li Weidong Le Living reference work entry Tics are defined as involuntary, sudden, nonrhythmic, rapid movements and/or sounds, with onset in childhood or adolescence. The .....

  • Saved

Neuroleptic Agent Toxicity

Neuroleptic Agent Toxicity

Source : https://www.ncbi.nlm.nih.gov/books/NBK554608/

Neuroleptic agents, otherwise known as 'antipsychotics,' are a broad category of medications initially developed to treat psychosis arising from a large spectrum of psychiatric and organic causes. Over the last .....

  • Saved

8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects

8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects

Source : https://www.scielo.br/scielo.php?pid=S1984-82502020000100508&script=sci_arttext

Article INTRODUCTION MATERIAL AND METHODS Drugs and chemicals FCS303 was synthesized by the Pechmann reaction (Potdar, Mohile, Salunkhe, 2001 ), in which coumarin was obtained by condensation of sesamol with .....

  • Saved

The Effects of Valbenazine on Tardive Dyskinesia in Older and Younger Patients - PubMed

The Effects of Valbenazine on Tardive Dyskinesia in Older and Younger Patients - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/31617235/

1 Departments of Psychiatry and of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH. 2 Departments of Psychiatry and of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH. .....

  • Saved

Unusual Phenomenologies

Unusual Phenomenologies

Source : https://link.springer.com/chapter/10.1007/978-3-030-36975-0_14

Steven J. Frucht Pichet Termsarasab Unusual movement disorders present a challenge for the practicing clinician, both in recognition and management. This chapter reviews the phenomenology of five unusual movement disorders: .....

  • Saved

PRIME PubMed | A unifying theory for the pathoetiologic mechanism of tardive dyskinesia

PRIME PubMed | A unifying theory for the pathoetiologic mechanism of tardive dyskinesia

Source : https://www.unboundmedicine.com/medline/citation/32200182/A_unifying_theory_for_the_pathoetiologic_mechanism_of_tardive_dyskinesia

Chronic treatment with dopamine D2 receptor antagonists has been proposed to lead to dopamine receptor supersensitivity. Frequently, this is conceptualized as upregulation or changes in the structure or function of .....