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Assesment of Risk Factors for Tardive Dyskinesia - PubMed

1 Melek Kanarya Vardar, MD, Psychiatrist. Baǧcilar Education and Research Hospital Psychiatry Department. Mehmet Emin Ceylan, MD, PHD, Professor of Psychiatry. Üsküdar University, Faculty of Humanities and Social Sciences, Department ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32733110/

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Effectively treating both tardive dyskinesia and underlying psychiatric condition

Tardive Dyskinesia, or involuntary and uncontrolled movements in patients with psychiatric disorders, is not a symptom of underlying disease, but rather a side effect of their drug treatment, typically associated with antipsychotic therapies that inhibit dopamine receptors. As such, patients with psychotic disorders such as schizophrenia or bipolar disorder are commonly affected by TD, as well as those prescribed antipsychotics over a prolonged period for other conditions such as major depressive disorder.

In some cases, TD can cause functional impairment, interfering with a patient’s quality of life. It can be embarrassing, socially isolating, and can often add to the stigma related to their mental illness. Proper management of TD is therefore equally as important as managing the underlying psychiatric disorder, in order to provide the best treatment outcome possible. FDA-approved treatments for TD are available, allowing targeted improvement of involuntary movements while maintaining antipsychotic use. Lowering the antipsychotic dose may compromise the primary treatment goal and may result in a relapse with accompanying psychotic or depressive episode.

To what extent does a patient’s TD complicate their overall treatment? Knowing the potential functional, physical, and social stigma issues, how important would you consider managing TD for patient quality of life/outcomes?

47-Year-Old Woman with Involuntary Jaw Movements

Janice, a 47-year-old patient, has a long-standing depressive mood disorder. Her symptoms include poor sleep quality, inability to concentrate, low self-esteem, ..... see more

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Hospital utilization rates following antipsychotic dose reduction in mood disorders: implications for treatment of tardive dyskinesia

The relative benefits and risks of long-term maintenance treatment with antipsychotics have not been well studied in patients with bipolar disorder and major depressive disorder. For example, while antipsychotic dose ..... see more

Source : https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02748-0

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Advances in Tardive Dyskinesia:

 PUBLISHED AS A SUPPLEMENT TO    A Review of Recent Literature Brian J. Miller, MD, PhD, MPH Dr Miller is Associate Professor, Department of Psychiatry and Health ..... see more

Source : https://deemagclinic.com/2020/05/08/advances-in-tardive-dyskinesia/

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Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part ... : Journal of Psychiatric Practice®

experiencing DDIs, how to recognize such DDIs, strategies for avoiding and/or minimizing adverse outcomes from such DDIs, and pharmacokinetic considerations concerning DDIs in psychiatric practice. The fourth and fifth columns ..... see more

Source : https://journals.lww.com/practicalpsychiatry/Abstract/2019/07000/Drug_Drug_Interactions__DDIs__in_Psychiatric.6.aspx

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Tremor and Other Hyperkinetic Movements

Chorea is a hyperkinetic movement disorder consisting of rapid involuntary movements that flow from part of the body to another. The mechanism generating this movement disorder is hypothesized to result ..... see more

Source : https://tremorjournal.org/articles/10.5334/tohm.351/

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(PDF) Barriers to stopping neuroleptic (antipsychotic) treatment in people with schizophrenia, psychosis or bipolar disorder

Most guidelines recommend long-term, indefinite neuroleptic (or antipsychotic) treatment for people with schizophrenia, recurrent psychosis or bipolar disorder, on the basis that these medications reduce the chance of relapse. However, ..... see more

Source : https://www.researchgate.net/publication/342721536_Barriers_to_stopping_neuroleptic_antipsychotic_treatment_in_people_with_schizophrenia_psychosis_or_bipolar_disorder

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Psychotropic medications induced parkinsonism and akathisia in people attending follow-up treatment at Jimma Medical Center, Psychiatry Clinic

Objective To determine the magnitude and factors associated with psychotropic drug-induced parkinsonism and akathisia among mentally ill patients. Methods A hospital-based cross-sectional study was conducted with a total of 410 ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235365

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Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders

Modulation of subthalamic nucleus (STN) firing patterns with injections of depolarizing currents into the STN is an important advance for the treatment of hypokinetic movement disorders, especially Parkinson's disease (PD). ..... see more

Source : https://www.nature.com/articles/s41598-020-65211-w

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Dyskinesia Is Most Centrally Situated in an Estimated Network of Extrapyramidal Syndrome in Asian Patients With Schizophrenia: Findings From Research on Asian Psychotropic Prescription Patterns for Antipsychotics - PubMed

Background: Network analysis provides a new viewpoint that explicates intertwined and interrelated symptoms into dynamic causal architectures of symptom clusters. This is a process called 'symptomics' and is concurrently applied ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32580668/

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RE-KINECT: A Prospective Study of the Presence and... : Journal of Clinical Psychopharmacology

disorder. Based on clinician observation and assessment, patients were assigned to cohort 1 (without involuntary movements or with non-TD involuntary movements) or cohort 2 (with involuntary movements confirmed by clinician ..... see more

Source : https://journals.lww.com/psychopharmacology/fulltext/2020/05000/re_kinect__a_prospective_study_of_the_presence_and.7.aspx

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Twenty-Nine-Year-Old With Tardive Dyskinesia

A 29-year-old male presents for a three-month follow-up appointment after being hospitalized for psychotic disorder, not otherwise specified. He began treatment for bipolar disorder six ..... see more

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Community Mental Health Care Delivery During the COVID-19 Pandemic: Practical Strategies for Improving Care for People with Serious Mental Illness

The COVID-19 pandemic has presented a formidable challenge to care continuity for community mental health clients with serious mental illness and for providers who have had to quickly pivot the ..... see more

Source : https://link.springer.com/article/10.1007/s10597-020-00662-z

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Advances in Tardive Dyskinesia:

 PUBLISHED AS A SUPPLEMENT TO    A Review of Recent Literature Brian J. Miller, MD, PhD, MPH Dr Miller is Associate Professor, Department of Psychiatry and Health ..... see more

Source : https://deemagclinic.com/2020/05/08/advances-in-tardive-dyskinesia/

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Antidepressants and movement disorders: a postmarketing study in the world pharmacovigilance database

Antidepressants-induced movement disorders are rare and imperfectly known adverse drug reactions. The risk may differ between different antidepressants and antidepressants' classes. The objective of this study was to assess the ..... see more

Source : https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02711-z

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Extrapyramidal Symptoms (EPS)

Extrapyramidal side effects (EPS), commonly referred to as drug-induced movement disorders are among the most common adverse drug effects patients experience from dopamine-receptor blocking agents. It was first described in ..... see more

Source : https://www.ncbi.nlm.nih.gov/books/NBK534115/

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Association of Regulatory Variants of Dopamine β-Hydroxylase With Cognition and Tardive Dyskinesia in Schizophrenia Subjects - PubMed

1 Department of Genetics, University of Delhi South Campus, New Delhi, India. 2 Department of Psychiatry, Postgraduate Institute of Medical Education and Research-Dr. Ram Manohar Lohia Hospital, New Delhi, India. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/31913053/

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Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders

Modulation of subthalamic nucleus (STN) firing patterns with injections of depolarizing currents into the STN is an important advance for the treatment of hypokinetic movement disorders, especially Parkinson's disease (PD). ..... see more

Source : https://www.nature.com/articles/s41598-020-65211-w

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The role of glutamate receptors and their interactions with ... : Behavioural Pharmacology

cal hypothesis of tardive dyskinesia development includes dopaminergic imbalance in the direct and indirect pathways of the basal ganglia, cholinergic deficiency, serotonin receptor disturbances, neurotoxicity, oxidative stress, and changes in ..... see more

Source : https://journals.lww.com/behaviouralpharm/Abstract/9000/The_role_of_glutamate_receptors_and_their.99179.aspx

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22 yo male with SchizoAffective Disorder, OCD, Tourettes treated with Abilify, Lithium, Prozac who now develops TD in leg with spasticity and pain. Taken off Abilify and Schizophrenia starting to ..... see more

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I would like an Ingrezza representative to call on me, please: Arthur N Papas, MD 781-431-7399.
Thank you.

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Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms

We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Protein-protein interaction (PPI) networks ..... see more

Source : https://link.springer.com/article/10.1007/s00213-020-05526-8

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Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms

We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Protein-protein interaction (PPI) networks ..... see more

Source : https://link.springer.com/article/10.1007/s00213-020-05526-8

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Parkinson's dyskinesia mechanism explained

Many people with Parkinson's disease eventually develop debilitating movements called dyskinesia, a side effect of their much-needed dopamine replacement medication. The mechanism underlying this unwanted side effect has been unknown, ..... see more

Source : https://www.sciencedaily.com/releases/2020/05/200501150558.htm

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RE-KINECT: A Prospective Study of the Presence and... : Journal of Clinical Psychopharmacology

disorder. Based on clinician observation and assessment, patients were assigned to cohort 1 (without involuntary movements or with non-TD involuntary movements) or cohort 2 (with involuntary movements confirmed by clinician ..... see more

Source : https://journals.lww.com/psychopharmacology/FullText/2020/05000/RE_KINECT__A_Prospective_Study_of_the_Presence_and.7.aspx

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Use of Valbenazine in a 54-Year-Old Female with Severe Tardive Dyskinesia

Tardive dyskinesia (TD) is a serious and often irreversible involuntary muscle movement that involves the face, lips, tongue, trunk, and extremities. TD is a risk in the use of antipsychotic ..... see more

Source : https://www.cureus.com/articles/25784-use-of-valbenazine-in-a-54-year-old-female-with-severe-tardive-dyskinesia

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International Journal of Medical Reviews and Case Reports

Abstract Aim of study: The aim of our study is to investigate the role of the age, gravida, parity, blood group in the development of GTD also significance of the ..... see more

Source : https://mdpub.net/?mno=29208

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Dystonia

Maria Fiorella Contarino Joachim K. Krauss Dystonic syndromes can be complex and present with different characteristics. Both accurate clinical diagnosis and characterization of dystonia can be very challenging and require ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-36346-8_14

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The Effects of the Rome IV Criteria on Pediatric Gastrointestinal Practice

To evaluate the impact of the implementation of the Rome IV criteria on pediatric gastrointestinal practice. In 2016, the Rome IV criteria were published, providing an update of symptom-based criteria ..... see more

Source : https://link.springer.com/article/10.1007/s11894-020-00760-8

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A CASE OF TARDIVE DYSKINESIA (TD) IN A PATIENT WITH NON SQUAMOUS CELL CARCINOMA BEING TREATED WITH ARIPIPRAZOLE

Download Citation | A CASE OF TARDIVE DYSKINESIA (TD) IN A PATIENT WITH NON SQUAMOUS CELL CARCINOMA BEING TREATED WITH ARIPIPRAZOLE | Introduction Aripiprazole is an atypical antipsychotic that is ..... see more

Source : https://www.researchgate.net/publication/339920864_A_CASE_OF_TARDIVE_DYSKINESIA_TD_IN_A_PATIENT_WITH_NON_SQUAMOUS_CELL_CARCINOMA_BEING_TREATED_WITH_ARIPIPRAZOLE

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Case report of first-episode psychotic symptoms in a patient with early-onset Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder featuring the behavioral and psychological symptoms of dementia. Patients with early-onset AD that exhibits first as psychotic symptoms usually lack obvious cognitive impairment, ..... see more

Source : https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02537-9

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Treatment of tics associated with Tourette syndrome

Motor and phonic tics associated with Tourette syndrome (TS) can range in severity from barely perceptible to disabling and most patients have a variety of behavioral co-morbidities, particularly, attention deficit ..... see more

Source : https://link.springer.com/article/10.1007/s00702-019-02105-w

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The Management of Dementia

The management of dementia Topics covered: Introduction Assessment Screening for dementia History and examination Screening assessments and investigations Communication and consent Cognitive symptoms Psychological techniques Elderly people Younger people with ..... see more

Source : https://www.enetmd.com/content/management-dementia

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Psychopharmacotherapy in Patients with Tics and Other Motor Disorders

Yijing Bai Long Niu Song Li Weidong Le Living reference work entry Tics are defined as involuntary, sudden, nonrhythmic, rapid movements and/or sounds, with onset in childhood or adolescence. The ..... see more

Source : https://link.springer.com/referenceworkentry/10.1007/978-3-319-56015-1_257-1

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Neuroleptic Agent Toxicity

Neuroleptic agents, otherwise known as 'antipsychotics,' are a broad category of medications initially developed to treat psychosis arising from a large spectrum of psychiatric and organic causes. Over the last ..... see more

Source : https://www.ncbi.nlm.nih.gov/books/NBK554608/

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8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects

Article INTRODUCTION MATERIAL AND METHODS Drugs and chemicals FCS303 was synthesized by the Pechmann reaction (Potdar, Mohile, Salunkhe, 2001 ), in which coumarin was obtained by condensation of sesamol with ..... see more

Source : https://www.scielo.br/scielo.php?pid=S1984-82502020000100508&script=sci_arttext

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The Effects of Valbenazine on Tardive Dyskinesia in Older and Younger Patients - PubMed

1 Departments of Psychiatry and of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH. 2 Departments of Psychiatry and of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/31617235/

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Unusual Phenomenologies

Steven J. Frucht Pichet Termsarasab Unusual movement disorders present a challenge for the practicing clinician, both in recognition and management. This chapter reviews the phenomenology of five unusual movement disorders: ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-36975-0_14

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PRIME PubMed | A unifying theory for the pathoetiologic mechanism of tardive dyskinesia

Chronic treatment with dopamine D2 receptor antagonists has been proposed to lead to dopamine receptor supersensitivity. Frequently, this is conceptualized as upregulation or changes in the structure or function of ..... see more

Source : https://www.unboundmedicine.com/medline/citation/32200182/A_unifying_theory_for_the_pathoetiologic_mechanism_of_tardive_dyskinesia