Skip to main content
micro-community-banner
 
  • Saved

made a Post

Benign Presentation Following Massive Deutetrabenazine Overdose

Deutetrabenazine (DTBZ) (Austedo®) is a novel vesicular monoamine transporter 2 (VMAT2) inhibitor, which acts by blocking dopamine release and other monoamines from neuronal vesicles. Although this drug is considered the ..... see more

Source : https://www.cureus.com/articles/49130-benign-presentation-following-massive-deutetrabenazine-overdose

  • Saved

made a Post

Patient perspective of tardive dyskinesia: results from a social media listening study

Background Tardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with prolonged exposure to dopamine receptor blocking agents such as antipsychotics. With the expanding use of antipsychotics, ..... see more

Source : https://link.springer.com/article/10.1186/s12888-021-03074-9

  • Saved

made a Post

Antiemetics and QT Prolongation

By Ofer Fass, MD Introduction QT interval prolongation is a common side effect shared among the most effective antiemetic classes. The risk of QT prolongation is exacerbated by electrolyte abnormalities ..... see more

Source : https://www.clinicalcorrelations.org/2021/01/15/antiemetics-and-qt-prolongation/

  • Saved

made a Post

Neuroimaging Characteristics of Patients with Chronic Schizophren...: Ingenta Connect

Objective: To investigate the improvement of melatonin in cognitive function and safety of schizophrenia patients with tardive dyskinesia (TD). At the same time, the neuroimaging characteristics of patients with chronic ..... see more

Source : https://www.ingentaconnect.com/contentone/asp/jmihi/2021/00000011/00000001/art00028

  • Saved

made a Post

Movement disorders in psychiatric patients

The observability of movement gives it advantages when trying to draw connections between brain and mind. Disturbed motor function pervades schizophrenia, though it is difficult now to subtract the effects ..... see more

Source : https://neurologyopen.bmj.com/content/2/2/e000057

  • Saved

made a Post

Resolution of tardive tremor after bilateral subthalamic nucleus deep brain stimulation placement - Surgical Neurology International

Tardive dyskinesia (TD) is a complex iatrogenic movement disorder that can manifest as orolingual, truncal, or respiratory dyskinesia as well as dystonia, tremor, chorea, myoclonus, akathisia, or Parkinsonism.[,] It is ..... see more

Source : https://surgicalneurologyint.com/surgicalint-articles/resolution-of-tardive-tremor-after-bilateral-subthalamic-nucleus-deep-brain-stimulation-placement/

Seventy-Two-Year-Old Male Becomes Non-Compliant with His Medication Routine

A 72-year-old male with a history of Parkinson's disorder, schizophrenia, hypertension and depression presents to you. Though he has typically been ..... see more

Show More Comments

  • from Generation NP 1 month 1 week
    I would first determine for sure that he is experiencing TD before starting Ingrezza, particularly because he also has Parkinson's (so it might be difficult to differentiate). If Abilify is Show More
  • from Generation NP 1 month 2 weeks
    Switch to anothet atypical antipsychotic and start Ingrezza immediately.
  • Saved

made a Post

Recognition and Treatment of Tardive Dyskinesia in Individuals with Intellectual Disability - PubMed

Individuals with intellectual disability (ID) commonly suffer from comorbid psychiatric and behavioral disorders that are frequently treated by antipsychotic medications. All individuals exposed to first- and second/third- generation antipsychotics are ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33414976/

  • Saved

made a Post

Copulatory Dyskinesia: Pathognomonic Manifestation of Tardive Dyskinesia

Tardive dyskinesia (TD) is an iatrogenic movement disorder resulting from exposure to neuroleptics, also known as dopamine-receptor blocking agents (DRBAs). The disorder is characterized by repetitive, stereotypic movements involving various ..... see more

Source : https://tremorjournal.org/articles/10.5334/tohm.585/

  • Saved

made a Post

Clinical Spectrum of Drug-Induced Movement Disorders: A Study of 97 Patients

Articles from Tremor and Other Hyperkinetic Movements are provided here courtesy of Center for Digital Research and Scholarship at Columbia University Libraries/Information Services see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747762/

  • Saved

85-year-old woman presents with tardive dyskinesia

History of Present Illness: Six months prior to today's visit, this 85-year-old patient experienced a fall while walking home from a local bakery. She ..... see more

Show More Comments

  • Saved

made a Post

Recognition and Treatment of Tardive Dyskinesia in Individuals with Intellectual Disability

Individuals with intellectual disability (ID) commonly suffer from comorbid psychiatric and behavioral disorders that are frequently treated by antipsychotic medications. All individuals exposed to first- and second/third- generation antipsychotics are ..... see more

Source : https://www.hindawi.com/journals/crips/2020/8886980/

  • Saved

made a Post

Values, Meanings, Hermeneutics and Mental Health

Michael TH Wong Mary (not her real name), the woman whose story is described below, was seen at the Neuropsychiatry Clinic of the Queen Mary Hospital in Hong Kong. This ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-47852-0_40

  • Saved

made a Post

Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: a resting-state fMRI study

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33279570/

  • Saved

made a Post

Movement disorders in psychiatric patients

The observability of movement gives it advantages when trying to draw connections between brain and mind. Disturbed motor function pervades schizophrenia, though it is difficult now to subtract the effects ..... see more

Source : https://neurologyopen.bmj.com/content/2/2/e000057

  • Saved

made a Post

Recent Advances in the Pharmacology of Tardive Dyskinesia

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33124584/

  • Saved

made a Post

Psychopharmacology and Brain-Based Therapies

Describe how the majority of psychoactive drugs work in the brain. Describe the most common drugs used in the treatment of disorders. Describe why grapefruit is dangerous to consume with ..... see more

Source : https://psychology.pressbooks.tru.ca/chapter/16-2-psychopharmcology/

  • Saved

made a Post

Prescription of Anticholinergics in Tardive Syndromes: A "Dual Center" Survey among Psychiatrists

Background and Objectives . Anticholinergics have been proposed in the therapy of tardive syndromes since the early 60 s, despite only anecdotal reports of a positive effect and a lack of ..... see more

Source : https://www.hindawi.com/journals/pd/2020/8870945/

  • Saved

made a Post

Revisiting Tardive Dyskinesia: Focusing on the Basics of Identification and Treatment

Forgot your login? GET HELP The use of second-generation antipsychotics has not eliminated tardive dyskinesia (TD), and the prevalence of the disorder is higher than commonly realized. The involuntary movements ..... see more

Source : https://www.psychiatrist.com/JCP/article/Pages/evaluating-and-treating-tardive-dyskinesia.aspx

  • Saved

Commented on 's Post


42-Year-Old Male with Long History of Bipolar Disorder

Don is a 42-year old with an almost 20-year history of bipolar disorder. When diagnosed, he received ..... see more

Show More Comments

  • 3 months 1 week
    The problem with the solution is the burden of clothes the pain and the frequency of bloodwork as well as the risk factors of weekends and metabolic issues. I’m not Show More
  • 4 months
    The initial dose of Haldol was too high. The second Haldol dose was likely too low. Olanzapine and Abilify options were tried but apparently without success in control of Show More
  • Saved

made a Post

Neurocrine Biosciences Honors Mental Health Month and Raises Awareness of Tardive Dyskinesia and its Impact on Patients

The only place for free North American stock rankings incorporating insider commitment. Get stock quotes, news, fundamentals and easy to read SEC and SEDI insider filings. Home of the insider ..... see more

Source : https://www.canadianinsider.com/neurocrine-biosciences-honors-mental-health-month-and-raises-awareness-of-tardive-dyskinesia-and-its-impact-on-patients

  • Saved

made a Post

How to Assess Tardive Dyskinesia Symptom Improvement With Measurement-Based Care.

​​​​​​ Clinicians now have 2 effective and well-tolerated vesicular monoamine transporter 2 (VMAT2) inhibitors-valbenazine and deutetrabenazine-for the treatment of patients with tardive dyskinesia (TD), a severe and potentially irreversible side ..... see more

Source : https://europepmc.org/article/med/33147658

  • Saved

made a Post

Collaborating With Patients to Make Treatment Decisions Based on Benefits and Risks of Medications Associated With Tardive Dyskinesia.

Collaborating With Patients to Make Treatment Decisions Based on Benefits and Risks of Medications Associated With Tardive Dyskinesia. see more

Source : https://europepmc.org/article/med/33147657

  • Saved

Commented on 's Post

Does This Young Male Patient Have Tardive Dyskinesia?

As a 19-year-old, this male patient was diagnosed with bipolar disorder and was prescribed olanzapine and valproic acid with good results. ..... see more

Show More Comments

  • 3 months 1 week
    It sounds like this is a case of target dyskinesia. The description is congruent. The question is treatment going forward as stabilization with olanzapine makes it risky to switch Show More
  • 3 months 1 week
    5 years of Olanzapine and VPA with positive response at unclear Olanzapine dose. At some point wasn't doing well with either negative symptoms, depressive or psychotic symptoms and noncompliance. Show More
  • Saved

made a Post

Collaborating With Patients to Make Treatment Decisions Based on Benefits and Risks of Medications Associated With Tardive Dyskinesia.

Collaborating With Patients to Make Treatment Decisions Based on Benefits and Risks of Medications Associated With Tardive Dyskinesia. see more

Source : https://europepmc.org/article/med/33147657

  • Saved

made a Post

How to Assess Tardive Dyskinesia Symptom Improvement With Measurement-Based Care

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33147658/

  • Saved

made a Post

Association between the IL10 rs1800896 Polymorphism and Tardive Dyskinesia in Schizophrenia

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33059393/

  • Saved

made a Post

Tremor and Other Hyperkinetic Movements

Drug-induced movement disorders (DIMDs) constitute an important treatable subgroup of movement disorder. Recently, different DIMDs are classified into eight categories, according to the fifth edition of the 'Diagnostic and Statistical ..... see more

Source : https://tremorjournal.org/articles/10.5334/tohm.554/

  • Saved

made a Post

Association between the IL10 rs1800896 Polymorphism and Tardive Dyskinesia in Schizophrenia

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33059393/

  • Saved

made a Post

A genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesia

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33065217/

Reactive Oxygen Species and Selenium in Epilepsy and in Other Neurological Disorders | IntechOpen

Oxidative stress has been implicated in epilepsy and various neurodegenerative disorders. In this review, we elaborate oxidative stress-mediated neuronal loss and assess the role of selenium in some neurological disorders ..... see more

Source : https://www.intechopen.com/books/personalized-medicine-in-relation-to-redox-state-diet-and-lifestyle/reactive-oxygen-species-and-selenium-in-epilepsy-and-in-other-neurological-disorders

Show More Comments

  • 4 months
    based on how long they had been stable and how long they had been on their dosage of psychotropic medication I would first consider a trial reduction of their medication. Show More
  • from Generation NP 4 months
    I would start ingrezza as well . Maybe titrate the dose of the antipsychotics . AIMS testing would be performed at each visit, as the symptoms should decrease. Austedo would Show More
  • Saved

made a Post

Overcoming barriers to effective management of tardive dyskinesia | NDT

Stanley N Caroff Corporal Michael J Crescenz VA Medical Center, and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Abstract: Tardive dyskinesia (TD) is a heterogeneous syndrome ..... see more

Source : https://www.dovepress.com/overcoming-barriers-to-effective-management-of-tardive-dyskinesia-peer-reviewed-article-NDT

  • Saved

made a Post

Tremor and Other Hyperkinetic Movements

A tremor is an involuntary, rhythmic and oscillatory movement of one or more body parts at a fixed amplitude and frequency [1 ]. A palatal tremor (PT) is a rare ..... see more

Source : https://tremorjournal.org/articles/10.5334/tohm.188/

  • Saved

made a Post

Evidence-Based Review of Current Botulinum Toxin Treatment Indications in Medicine

Dhanya Vijayakumar Joseph Jankovic Botulinum neurotoxin (BoNT) has been increasingly used not only as a cosmetic drug but, more importantly, it has emerged as the most versatile therapeutic, utilized in ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-50691-9_4

  • Saved

made a Post

I am wondering since most of us are doing telepsychiatry now due to the covid outbreak, are my colleagues seeing an increase in compliance for attending remote appointments with individuals ..... see more

  • Saved

made a Post

Nausea and vomiting of pregnancy: Treatment and outcome - UpToDate

INTRODUCTION - Nausea with or without vomiting is common in early pregnancy. Severe vomiting resulting in hypovolemia and weight loss is termed hyperemesis gravidarum and occurs infrequently. Symptoms usually resolve ..... see more

Source : https://www.uptodate.com/contents/nausea-and-vomiting-of-pregnancy-treatment-and-outcome

  • Saved

made a Post

Neurological complications of psychiatric drugs: clinical features and management - PubMed

This paper reviews the main neurological complications of psychiatric drugs, in particular antipsychotics and antidepressants. Extrapyramidal syndromes include acute dystonia, parkinsonism, akathisia, tardive dyskinesia and tardive dystonia. Extrapyramidal symptoms (EPS) ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/18098217/

  • Saved

made a Post

Liver enzyme CYP2D6 gene and tardive dyskinesia - PubMed

doi: 10.2217/pgs-2020-0065. Online ahead of print. 1 Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada. 2 Department ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32969762/

  • Saved

Commented on 's Post

Neurobiological mechanisms associated with antipsychotic drug-induced dystonia - PubMed

Dystonia is by far the most intrusive and invalidating extrapyramidal side effect of potent classical antipsychotic drugs. Antipsychotic drug-induced dystonia is classified in both acute and tardive forms. The incidence ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32900259/

Show More Comments

  • 5 months
    Acute dystonia was most common with IM use of Haldol for control of acute agitation and less often with Prolixin and Navane.However with 2nd generation antipsychotics incidences of acute dystonia Show More

Elderly Male With Extensive Medical History Presents with Possible Tardive Dyskinesia

A 71-year-old male presents with an extensive medical history with a worrisome addition of abnormal movements in his ..... see more

Show More Comments

  • 5 months
    at this gentleman's age , there are many confounding issues, tho there is a strong indication that abrupt ( even gradual tapering )of abilify may cause this Sx group , Show More
  • from Generation NP 5 months 1 week
    I would personally recommned a neurological examination for a specialist's opinion on the actual type of movement disorder this person is displaying before I actually prescribe an agent such as Show More
  • Saved

made a Post

Movement disorders induced by psychiatric drugs that do not block dopamine receptors - PubMed

doi: 10.1016/j.parkreldis.2020.08.031. Online ahead of print. 1 Butler Hospital, Division of Movement Disorders, Warren Alpert Medical School of Brown University, Providence, RI, USA. Electronic address: Joseph_Friedman@brown.edu. doi: 10.1016/j.parkreldis.2020.08.031. Online ahead ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32871538/

  • Saved

made a Post

Vulnerable Populations: Differential Impact of COVID-19 on Populations with Severe Mental Illness - Journal of Psychiatry Reform

Mariam Abdurrahman MD, MSc, 1, ✉ Ana Hategan MD 2 Author information: 1 Part-time Lecturer, Staff Psychiatrist, Department of Psychiatry, University of Toronto, St. Joseph's Health Centre (a division of ..... see more

Source : https://journalofpsychiatryreform.com/2020/07/29/vulnerable-populations-differential-impact-of-covid-19-on-populations-with-severe-mental-illness/

  • Saved

Show More Comments

  • 5 months 2 weeks
    Many DRS don't know that Metoclopramide ( Reglan ) causes TD
  • 5 months 2 weeks
    Unmasking" TD is well described. Amantadine, Vit E, antichoinergics of no use & some may worsen Sxs. If stable on current APD, may want to lower dose to MED. But Show More