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Movement disorders induced by psychiatric drugs that do not block dopamine receptors - PubMed

doi: 10.1016/j.parkreldis.2020.08.031. Online ahead of print. 1 Butler Hospital, Division of Movement Disorders, Warren Alpert Medical School of Brown University, Providence, RI, USA. Electronic address: Joseph_Friedman@brown.edu. doi: 10.1016/j.parkreldis.2020.08.031. Online ahead ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32871538/

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Neurobiological mechanisms associated with antipsychotic drug-induced dystonia - PubMed

Dystonia is by far the most intrusive and invalidating extrapyramidal side effect of potent classical antipsychotic drugs. Antipsychotic drug-induced dystonia is classified in both acute and tardive forms. The incidence ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32900259/

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Vulnerable Populations: Differential Impact of COVID-19 on Populations with Severe Mental Illness - Journal of Psychiatry Reform

Mariam Abdurrahman MD, MSc, 1, ✉ Ana Hategan MD 2 Author information: 1 Part-time Lecturer, Staff Psychiatrist, Department of Psychiatry, University of Toronto, St. Joseph's Health Centre (a division of ..... see more

Source : https://journalofpsychiatryreform.com/2020/07/29/vulnerable-populations-differential-impact-of-covid-19-on-populations-with-severe-mental-illness/

Elderly Male With Extensive Medical History Presents with Possible Tardive Dyskinesia

A 71-year-old male presents with an extensive medical history with a worrisome addition of abnormal movements in his ..... see more

THOMAS VALENTE, Frank Abenante Commented on a Post
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How would you treat a patient with tardive dyskinesia (TD)?

Patients with psychiatric disorders can present with involuntary, uncontrolled movements that are collectively called tardive dyskinesia (TD). The involuntary movements are repetitive, persistent, and can be observed in the face, the jaw, tongue and lips, as well as in the extremities or trunk. Facial movements include tongue protrusion, grimacing, and lip smacking. It can be embarrassing, socially isolating, and can often add to the stigma related to their mental illness.

Tardive Dyskinesia is not a symptom of the underlying disease, but rather a side effect of their drug treatment, typically associated with antipsychotic therapies that inhibit dopamine receptors. Patients with schizophrenia or bipolar disorder are commonly affected by TD, as well as patients prescribed antipsychotics over a prolonged period for other conditions such as major depressive disorder. Between 20–30% of patients receiving long-term antipsychotics are thought to develop TD.

If a patient presented with TD and her psychiatric disorder was well-controlled, how would you treat that patient’s TD? What is your rationale for that treatment plan?

Teresa Brown, Manoj Waikar Commented on a Post
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Effectively treating both tardive dyskinesia and underlying psychiatric condition

Tardive Dyskinesia, or involuntary and uncontrolled movements in patients with psychiatric disorders, is not a symptom of underlying disease, but rather a side effect of their drug treatment, typically associated with antipsychotic therapies that inhibit dopamine receptors. As such, patients with psychotic disorders such as schizophrenia or bipolar disorder are commonly affected by TD, as well as those prescribed antipsychotics over a prolonged period for other conditions such as major depressive disorder.

In some cases, TD can cause functional impairment, interfering with a patient’s quality of life. It can be embarrassing, socially isolating, and can often add to the stigma related to their mental illness. Proper management of TD is therefore equally as important as managing the underlying psychiatric disorder, in order to provide the best treatment outcome possible. FDA-approved treatments for TD are available, allowing targeted improvement of involuntary movements while maintaining antipsychotic use. Lowering the antipsychotic dose may compromise the primary treatment goal and may result in a relapse with accompanying psychotic or depressive episode.

To what extent does a patient’s TD complicate their overall treatment? Knowing the potential functional, physical, and social stigma issues, how important would you consider managing TD for patient quality of life/outcomes?

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Hospital utilization rates following antipsychotic dose reduction in mood disorders: implications for treatment of tardive dyskinesia - PubMed

Patients with mood disorders who had antipsychotic dose reductions showed small but statistically significant increases in all-cause and mental health-related hospitalizations, which may lead to increased healthcare costs. These results ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32652964/

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Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis - Lancet Psychiatry - X-MOL

X-MOL提供的期刊论文更新,The Lancet Psychiatry--Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis,Jose M Rubio; Georgios Schoretsanitis; Majnu John; Jari Tiihonen; Heidi Taipale; ..... see more

Source : https://www.x-mol.com/paper/1296856909862281216

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Neuroleptics

James H. Nichols Neuroleptics are antipsychotic drugs that are used to treat schizophrenia and bipolar disorder. They are subdivided into "typical" and "atypical" drug classes, based on chemical structure and ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-42917-1_28

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57-Year-Old Man with Bilateral Jaw Twitching

A 57-year-old man was initially treated for bipolar mania with paroxetine, dosed at 20 mg daily, and then at 40 mg ..... see more

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Assesment of Risk Factors for Tardive Dyskinesia - PubMed

1 Melek Kanarya Vardar, MD, Psychiatrist. Baǧcilar Education and Research Hospital Psychiatry Department. Mehmet Emin Ceylan, MD, PHD, Professor of Psychiatry. Üsküdar University, Faculty of Humanities and Social Sciences, Department ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32733110/

47-Year-Old Woman with Involuntary Jaw Movements

Janice, a 47-year-old patient, has a long-standing depressive mood disorder. Her symptoms include poor sleep quality, inability to concentrate, low self-esteem, ..... see more

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Hospital utilization rates following antipsychotic dose reduction in mood disorders: implications for treatment of tardive dyskinesia

The relative benefits and risks of long-term maintenance treatment with antipsychotics have not been well studied in patients with bipolar disorder and major depressive disorder. For example, while antipsychotic dose ..... see more

Source : https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02748-0

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Advances in Tardive Dyskinesia:

 PUBLISHED AS A SUPPLEMENT TO    A Review of Recent Literature Brian J. Miller, MD, PhD, MPH Dr Miller is Associate Professor, Department of Psychiatry and Health ..... see more

Source : https://deemagclinic.com/2020/05/08/advances-in-tardive-dyskinesia/

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Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part ... : Journal of Psychiatric Practice®

experiencing DDIs, how to recognize such DDIs, strategies for avoiding and/or minimizing adverse outcomes from such DDIs, and pharmacokinetic considerations concerning DDIs in psychiatric practice. The fourth and fifth columns ..... see more

Source : https://journals.lww.com/practicalpsychiatry/Abstract/2019/07000/Drug_Drug_Interactions__DDIs__in_Psychiatric.6.aspx

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Tremor and Other Hyperkinetic Movements

Chorea is a hyperkinetic movement disorder consisting of rapid involuntary movements that flow from part of the body to another. The mechanism generating this movement disorder is hypothesized to result ..... see more

Source : https://tremorjournal.org/articles/10.5334/tohm.351/

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(PDF) Barriers to stopping neuroleptic (antipsychotic) treatment in people with schizophrenia, psychosis or bipolar disorder

Most guidelines recommend long-term, indefinite neuroleptic (or antipsychotic) treatment for people with schizophrenia, recurrent psychosis or bipolar disorder, on the basis that these medications reduce the chance of relapse. However, ..... see more

Source : https://www.researchgate.net/publication/342721536_Barriers_to_stopping_neuroleptic_antipsychotic_treatment_in_people_with_schizophrenia_psychosis_or_bipolar_disorder

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Psychotropic medications induced parkinsonism and akathisia in people attending follow-up treatment at Jimma Medical Center, Psychiatry Clinic

Objective To determine the magnitude and factors associated with psychotropic drug-induced parkinsonism and akathisia among mentally ill patients. Methods A hospital-based cross-sectional study was conducted with a total of 410 ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235365

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Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders

Modulation of subthalamic nucleus (STN) firing patterns with injections of depolarizing currents into the STN is an important advance for the treatment of hypokinetic movement disorders, especially Parkinson's disease (PD). ..... see more

Source : https://www.nature.com/articles/s41598-020-65211-w

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Dyskinesia Is Most Centrally Situated in an Estimated Network of Extrapyramidal Syndrome in Asian Patients With Schizophrenia: Findings From Research on Asian Psychotropic Prescription Patterns for Antipsychotics - PubMed

Background: Network analysis provides a new viewpoint that explicates intertwined and interrelated symptoms into dynamic causal architectures of symptom clusters. This is a process called 'symptomics' and is concurrently applied ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32580668/

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RE-KINECT: A Prospective Study of the Presence and... : Journal of Clinical Psychopharmacology

disorder. Based on clinician observation and assessment, patients were assigned to cohort 1 (without involuntary movements or with non-TD involuntary movements) or cohort 2 (with involuntary movements confirmed by clinician ..... see more

Source : https://journals.lww.com/psychopharmacology/fulltext/2020/05000/re_kinect__a_prospective_study_of_the_presence_and.7.aspx

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Twenty-Nine-Year-Old With Tardive Dyskinesia

A 29-year-old male presents for a three-month follow-up appointment after being hospitalized for psychotic disorder, not otherwise specified. He began treatment for bipolar disorder six ..... see more

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Community Mental Health Care Delivery During the COVID-19 Pandemic: Practical Strategies for Improving Care for People with Serious Mental Illness

The COVID-19 pandemic has presented a formidable challenge to care continuity for community mental health clients with serious mental illness and for providers who have had to quickly pivot the ..... see more

Source : https://link.springer.com/article/10.1007/s10597-020-00662-z

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Advances in Tardive Dyskinesia:

 PUBLISHED AS A SUPPLEMENT TO    A Review of Recent Literature Brian J. Miller, MD, PhD, MPH Dr Miller is Associate Professor, Department of Psychiatry and Health ..... see more

Source : https://deemagclinic.com/2020/05/08/advances-in-tardive-dyskinesia/

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Antidepressants and movement disorders: a postmarketing study in the world pharmacovigilance database

Antidepressants-induced movement disorders are rare and imperfectly known adverse drug reactions. The risk may differ between different antidepressants and antidepressants' classes. The objective of this study was to assess the ..... see more

Source : https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02711-z

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Extrapyramidal Symptoms (EPS)

Extrapyramidal side effects (EPS), commonly referred to as drug-induced movement disorders are among the most common adverse drug effects patients experience from dopamine-receptor blocking agents. It was first described in ..... see more

Source : https://www.ncbi.nlm.nih.gov/books/NBK534115/

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Association of Regulatory Variants of Dopamine β-Hydroxylase With Cognition and Tardive Dyskinesia in Schizophrenia Subjects - PubMed

1 Department of Genetics, University of Delhi South Campus, New Delhi, India. 2 Department of Psychiatry, Postgraduate Institute of Medical Education and Research-Dr. Ram Manohar Lohia Hospital, New Delhi, India. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/31913053/

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Hyperpolarization of the subthalamic nucleus alleviates hyperkinetic movement disorders

Modulation of subthalamic nucleus (STN) firing patterns with injections of depolarizing currents into the STN is an important advance for the treatment of hypokinetic movement disorders, especially Parkinson's disease (PD). ..... see more

Source : https://www.nature.com/articles/s41598-020-65211-w

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The role of glutamate receptors and their interactions with ... : Behavioural Pharmacology

cal hypothesis of tardive dyskinesia development includes dopaminergic imbalance in the direct and indirect pathways of the basal ganglia, cholinergic deficiency, serotonin receptor disturbances, neurotoxicity, oxidative stress, and changes in ..... see more

Source : https://journals.lww.com/behaviouralpharm/Abstract/9000/The_role_of_glutamate_receptors_and_their.99179.aspx

22 yo male with SchizoAffective Disorder, OCD, Tourettes treated with Abilify, Lithium, Prozac who now develops TD in leg with spasticity and pain. Taken off Abilify and Schizophrenia starting to ..... see more

I would like an Ingrezza representative to call on me, please: Arthur N Papas, MD 781-431-7399.
Thank you.

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Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms

We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Protein-protein interaction (PPI) networks ..... see more

Source : https://link.springer.com/article/10.1007/s00213-020-05526-8

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Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms

We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Protein-protein interaction (PPI) networks ..... see more

Source : https://link.springer.com/article/10.1007/s00213-020-05526-8

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Parkinson's dyskinesia mechanism explained

Many people with Parkinson's disease eventually develop debilitating movements called dyskinesia, a side effect of their much-needed dopamine replacement medication. The mechanism underlying this unwanted side effect has been unknown, ..... see more

Source : https://www.sciencedaily.com/releases/2020/05/200501150558.htm

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RE-KINECT: A Prospective Study of the Presence and... : Journal of Clinical Psychopharmacology

disorder. Based on clinician observation and assessment, patients were assigned to cohort 1 (without involuntary movements or with non-TD involuntary movements) or cohort 2 (with involuntary movements confirmed by clinician ..... see more

Source : https://journals.lww.com/psychopharmacology/FullText/2020/05000/RE_KINECT__A_Prospective_Study_of_the_Presence_and.7.aspx

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Use of Valbenazine in a 54-Year-Old Female with Severe Tardive Dyskinesia

Tardive dyskinesia (TD) is a serious and often irreversible involuntary muscle movement that involves the face, lips, tongue, trunk, and extremities. TD is a risk in the use of antipsychotic ..... see more

Source : https://www.cureus.com/articles/25784-use-of-valbenazine-in-a-54-year-old-female-with-severe-tardive-dyskinesia

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International Journal of Medical Reviews and Case Reports

Abstract Aim of study: The aim of our study is to investigate the role of the age, gravida, parity, blood group in the development of GTD also significance of the ..... see more

Source : https://mdpub.net/?mno=29208

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Dystonia

Maria Fiorella Contarino Joachim K. Krauss Dystonic syndromes can be complex and present with different characteristics. Both accurate clinical diagnosis and characterization of dystonia can be very challenging and require ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-36346-8_14

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The Effects of the Rome IV Criteria on Pediatric Gastrointestinal Practice

To evaluate the impact of the implementation of the Rome IV criteria on pediatric gastrointestinal practice. In 2016, the Rome IV criteria were published, providing an update of symptom-based criteria ..... see more

Source : https://link.springer.com/article/10.1007/s11894-020-00760-8

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A CASE OF TARDIVE DYSKINESIA (TD) IN A PATIENT WITH NON SQUAMOUS CELL CARCINOMA BEING TREATED WITH ARIPIPRAZOLE

Download Citation | A CASE OF TARDIVE DYSKINESIA (TD) IN A PATIENT WITH NON SQUAMOUS CELL CARCINOMA BEING TREATED WITH ARIPIPRAZOLE | Introduction Aripiprazole is an atypical antipsychotic that is ..... see more

Source : https://www.researchgate.net/publication/339920864_A_CASE_OF_TARDIVE_DYSKINESIA_TD_IN_A_PATIENT_WITH_NON_SQUAMOUS_CELL_CARCINOMA_BEING_TREATED_WITH_ARIPIPRAZOLE

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Case report of first-episode psychotic symptoms in a patient with early-onset Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder featuring the behavioral and psychological symptoms of dementia. Patients with early-onset AD that exhibits first as psychotic symptoms usually lack obvious cognitive impairment, ..... see more

Source : https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02537-9

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Treatment of tics associated with Tourette syndrome

Motor and phonic tics associated with Tourette syndrome (TS) can range in severity from barely perceptible to disabling and most patients have a variety of behavioral co-morbidities, particularly, attention deficit ..... see more

Source : https://link.springer.com/article/10.1007/s00702-019-02105-w

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The Management of Dementia

The management of dementia Topics covered: Introduction Assessment Screening for dementia History and examination Screening assessments and investigations Communication and consent Cognitive symptoms Psychological techniques Elderly people Younger people with ..... see more

Source : https://www.enetmd.com/content/management-dementia

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Psychopharmacotherapy in Patients with Tics and Other Motor Disorders

Yijing Bai Long Niu Song Li Weidong Le Living reference work entry Tics are defined as involuntary, sudden, nonrhythmic, rapid movements and/or sounds, with onset in childhood or adolescence. The ..... see more

Source : https://link.springer.com/referenceworkentry/10.1007/978-3-319-56015-1_257-1

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Neuroleptic Agent Toxicity

Neuroleptic agents, otherwise known as 'antipsychotics,' are a broad category of medications initially developed to treat psychosis arising from a large spectrum of psychiatric and organic causes. Over the last ..... see more

Source : https://www.ncbi.nlm.nih.gov/books/NBK554608/