Sleep and risk of hypertension in general American adults: the National Health and Nutrition Examination Surveys (2015-2018) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36129105/
Objective: The purpose of research is to investigate the associations of sleep factors separately and jointly with risk of hypertension. Methods: The National Health and Nutrition Examination Surveys (NHANES) is...
Conclusion: Sleep behaviors were cross-sectionally associated with a considerably higher hypertension risk.
Ethnic differences exist in sleepiness 3 Months after ischemic stroke
Source : https://www.sciencedirect.com/science/article/abs/pii/S1389945722011224?via=ihub
Mexican American compared to non-Hispanic white participants reported greater sleepiness 90 days after stroke. * This ethnic disparity persisted when controlling for confounding variables. * Respiratory event index measured soon...
Relevance: To examine the association between ethnicity and 90-day post-stroke subjective sleepiness, an important determinant of quality of life, as measured by the Epworth Sleepiness Scale (ESS), among ischemic stroke survivors.
Long-Term Outcome of a Series of Patients With Narcolepsy Type 1 and Comorbidity With Immunopathological and Autoimmune Diseases | Martinez-Orozco | Journal of Clinical Medicine Research
Source : https://www.jocmr.org/index.php/JOCMR/article/view/4758
Francisco J. Martinez-Orozco, Miguel Fernandez-Arquero, Jose L. Vicario, Laura Lillo-Triguero, Elena Ameyugo, Rosa Peraita-Adrados Abstract Background: The aim of this study was to evaluate the long-term outcome of our series...
Conclusions: The prevalence of AD/ID is high in our series, suggesting that NT1 might arise on a background of generalized susceptibility to immune-mediated processes. The occurrence of an ID can in turn influence the development of others in genetically predisposed individuals, which explains the increased associations observed in this...
Efficacy and Safety of Daridorexant in Older and Younger Adults with Insomnia Disorder: A Secondary Analysis of a Randomised Placebo-Controlled Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36098936/
doi: 10.1007/s40266-022-00977-4. Online ahead of print. 1 Center for Sleep Medicine, Charité, University Hospital Berlin, Berlin, Germany. 2 Department of Medicine, The Fourth People's Hospital of Guangyuan City, Guangyuan, China....
Conclusions: In older patients with insomnia, as in younger patients, the efficacy of daridorexant is maximal on night-time and daytime variables at the higher dose of 50 mg. Older patients particularly require this dose to improve daytime functioning. Older patients are not at an increased risk of adverse events or residual effects the next...
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Sleep Disorder Connect3yrKey Points • Source: Drugs & Aging • Conclusion: “In older patients with insomnia, as in younger patients, the efficacy of daridorexant is maximal on night-time and daytime variables at the higher dose of Show More
Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model
Source : https://www.sciencedirect.com/science/article/pii/S0091305722001435?via=ihub
Danavorexton shows rapid association and dissociation kinetics to OX2R. * Activation mode of endogenous OX2R by danavorexton is similar to that by orexin peptide. * Danavorexton can induce cortical arousal...
Conclusion/Relevance: These preclinical findings, together with upcoming clinical observations of danavorexton, could improve our understanding of the pathophysiology of NT1 and therapeutic potential of OX2R agonists.