Exploratory GABAa-informed control network modulates hyperarousal brain dynamics in chronic insomnia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40610759/
Chronic insomnia disorder is characterized by hyperarousal, a heightened cortical activation pattern that disrupts normal sleep. While hyperarousal has been linked to altered brain state dynamics, the underlying neurobiological mechanisms...
Study reveals that GABAa receptor distribution modulates unstable brain dynamics in chronic insomnia. Incorporating GABAergic data increases network control energy, suggesting a stabilizing role against hyperarousal-related state transitions.
Comparative efficacy and safety of daridorexant, lemborexant, and suvorexant for insomnia: a systematic review and network meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40555730/
Considering that there is no evidence that DORAs are associated with physiological tolerance, withdrawal symptoms, or rebound insomnia when abruptly discontinued, and that sleep architecture is not adversely affected, the...
Human melanopsin (OPN4) gene polymorphisms: a systematic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40556870/
The melanopsin (OPN4) gene is crucial in visual and non-visual processes. Certain single-nucleotide polymorphisms (SNPs) of this gene have been linked to altered light sensitivity, photoentrainment, sleep disorders, and metabolic...
This review identifies melanopsin gene variants associated with sleep disorders and chronotype changes, highlighting the P10L, I394T, and R168C SNPs as potential genetic contributors to disrupted circadian regulation.
A bibliometric analysis of wearable device research in sleep science: Trends and hotspots - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40527826/
This study provides a comprehensive overview of the current state of wearable device research in sleep science. By identifying key trends, influential researchers, and emerging research areas, this study offers...
This bibliometric study analyzes trends in wearable sleep device research from 2004–2025, identifying key contributors, emerging hotspots, and technologies crucial to advancing sleep disorder diagnosis and management.
Imaging advances to detect non-motor prodromal markers of Parkinson's disease and explore therapeutic translation opportunities - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40533452/
Parkinson's disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years. Identifying...
This review discusses imaging tools to detect early non-motor signs of Parkinson’s disease—like REM sleep behavior disorder—highlighting their value in predicting disease onset and enabling early neuroprotective therapies.