Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37153764/
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Conclusion: A2AR allosteric modulation may represent a new therapeutic avenue for sleep disruption associated with bipolar disorder or psychosis.
A proprietary black cumin oil extract ( Nigella sativa) (BlaQmax®) modulates stress-sleep-immunity axis safely: Randomized double-blind placebo-controlled study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37139438/
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Conclusion: BCO-5 significantly modulated the stress-sleep-immunity axis with no side effects and restored restful sleep.
Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1108682/full
IntroductionNarcolepsy type 1 (NT1) is a rare, chronic and disabling neurological disease causing excessive daytime sleepiness and cataplexy. NT1 is characterized pathologically by an almost complete loss of neurons producing...
Conclusions: Our findings suggest that identification and diagnosis of sleep disorders for veterans with SMI has improved over the past decade, though diagnoses still likely underrepresent actual prevalence of clinically relevant sleep concerns. Sleep concerns may be at particularly high risk of going untreated in veterans with...
Hypnotics and injuries among older adults with Parkinson's disease: a nested case-control design - BMC Geriatrics
Source : https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-023-03944-9
Background Patients with Parkinson's disease often experience sleep disorders. Hypnotics increase the risk of adverse events, such as injuries due to falls. In this study, we evaluated the association between...
Conclusions: Benzodiazepines and non-benzodiazepines, which are not recommended according to current guidelines, were the most prevalent among older adults with Parkinson’s disease. Benzodiazepines significantly increased the risk of injuries, and melatonin receptor agonists significantly increased the risk of femoral fractures.
Functional connectivity changes are correlated with sleep improvement in chronic insomnia patients after rTMS treatment
Source : https://www.frontiersin.org/articles/10.3389/fnins.2023.1135995/full
BackgroundRepetitive transcranial magnetic stimulation (rTMS) has been increasingly used as a treatment modality for chronic insomnia disorder (CID). However, our understanding of the mechanisms underlying the efficacy of rTMS is...
Conclusion: Based on these results, we established a link between alterations in functional connectivity and clinical outcomes of rTMS, which suggested that EEG-derived functional connectivity changes were associated with clinical improvement of rTMS in treating CID. These findings provide preliminary evidence that rTMS may improve insomnia...