Weight Loss and Sleep, Current Evidence in Animal Models and Humans
Source : https://www.mdpi.com/2072-6643/15/15/3431
Sleep is a vital process essential for survival. The trend of reduction in the time dedicated to sleep has increased in industrialized countries, together with the dramatic increase in the...
Conclusions/Relevance: Sleep and metabolic disorders are linked; therefore, identifying the physiological and molecular pathways involved in sleep regulation and metabolic homeostasis can play a major role in ameliorating the metabolic health of the individual. Approaches aimed at reducing body weight could provide benefits for both...
The burden of untreated insomnia disorder in a sample of 1 million adults: a cohort study - BMC Public Health
Source : https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-16329-9
Background Insomnia disorder is a highly prevalent, significant public health concern associated with substantial and growing health burden. There are limited real-world data assessing the burden of insomnia disorder on...
Conclusion: This large-scale study confirms the substantial burden of insomnia disorder on patients in a real-world setting, with significant daytime impairment and numerous comorbidities. This reinforces the need for timely insomnia disorder diagnosis and treatments that improve both sleep, as well as daytime functioning.
Daridorexant as a novel pharmacotherapeutic approach in insomnia: a systematic review and meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37526060/
www.clinicaltrials.gov identifiers are NCT03575104, NCT03545191, NCT03679884, and NCT02839200).
Conclusion: Daridorexant is a safer and efficacious agent for induction and maintenance of sleep for chronic insomnia.
Factors associated with insomnia symptoms over three years among premenopausal women with breast cancer - Breast Cancer Research and Treatment
Source : https://link.springer.com/article/10.1007/s10549-023-07058-z
Purpose We examined longitudinal trends and factors associated with insomnia over 3 years in a cohort of young breast cancer patients. Methods Women with stage I-III breast cancer at ≤ 45 years...
Conclusions: Insomnia symptoms were most frequent closer to breast cancer diagnosis and treatment, but persisted for some women who were older and those reporting higher hot flashes and depressive symptoms. Survivorship care should include assessing insomnia symptoms, particularly during and immediately after primary treatment. Implementing...
Role of the orexin system in the bidirectional relation between sleep and epilepsy: New chances for patients with epilepsy by the antagonism to orexin receptors? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37212716/
Epilepsy is a common neurological disorder, affecting patients of all ages, reducing the quality of life, and associated with several comorbidities. Sleep impairment is a frequent condition in patients with...
Conclusions/Relevance: The present review analyzes the preclinical and clinical evidence linking the orexin system to epilepsy, and hypothesizes a model in which the antagonism to the orexin system by DORAs can improve epilepsy by both a direct and a sleep-mediated (indirect) effect.