In phase 3 trials, the benefit-risk ratios for both lemborexant and daridorexant were favorable as measured by number needed to treat, number needed to harm, and likelihood to be helped or harmed. Indirect comparisons of lemborexant with daridorexant suggest an efficacy advantage for lemborexant and a tolerability advantage for daridorexant.

Researchers prospectively evaluated the frequency of orthostatic hypotension (OH) in a large multicenter isolated rapid eye movement sleep behavior disorder (iRBD) cohort. Compared with iRBD participants without OH, those with OH were older, reported older age of RBD symptom onset, and had worse olfaction.

Researchers investigated the spatiotemporal characteristics of sleep waveforms in temporal lobe epilepsy (TLE) and examine their association with cognition. They found a fundamental alteration of sleep micro-architecture in TLE, characterized by a reduction in spindle density and spindle-SO coupling, and these changes may contribute to...

Differences in sex, race, education, comorbidities, and obstructive sleep apnea-related symptoms exist between adults at high risk for obstructive sleep apnea who have and have not reported trouble sleeping to an healthcare provider. Men, minorities, and persons with lower educational attainment may be less likely to report trouble sleeping.

These findings confirm that EDS may be implicated in the development of dementia and indicate a weaker than expected role of cardiovascular burden in the relationship between EDS and DVC.