Advances in sleep genetics continue to uncover molecular pathways involved in circadian rhythm regulation, neuronal signaling, and sleep–wake stability. These findings may help refine understanding of neurologic sleep disorders and impaired daytime functioning.
Source : https://pubmed.ncbi.nlm.nih.gov/42251722/
The findings suggest that combining Pilates and myofunctional therapy may be a useful non-pharmacological strategy to improve sleep and psychosocial outcomes in individuals with obesity-associated OSA.
An 8-week program combining Pilates and myofunctional therapy improved sleep quality, daytime symptoms, mood, vitality, and quality-of-life measures in a patient with obesity-associated obstructive sleep apnea.
Did you know? Idiopathic hypersomnia is a central hypersomnolence disorder distinct from narcolepsy, characterized by prolonged, non-restorative sleep and severe sleep inertia. Low-sodium oxybate acts at GABA-B receptors to consolidate nighttime sleep and reduce excessive daytime sleepiness, offering a pathophysiologically driven treatment for this historically underserved patient population.
How confident are you in distinguishing idiopathic hypersomnia from other hypersomnolence disorders in your practice?
How confident are you in distinguishing idiopathic hypersomnia from other hypersomnolence disorders in your practice?
Source : https://pubmed.ncbi.nlm.nih.gov/42220922/
It can be concluded that many individuals may be potentially involved in insomnia disorder as pre-insomnia. The findings demonstrate that pre-insomnia and insomnia share very similar molecular mechanisms. The critical...
Gene expression analysis identified molecular signatures shared between insomnia and pre-insomnia states, highlighting inflammatory, apoptotic, and immune-related pathways alongside key regulatory genes linked to sleep disturbance.