The correlation between rapid eye movement sleep behavior disorder and the progress of Parkinson's disease: a systematic review and meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39086754/
https://www.crd.york.ac.uk/PROSPERO/#searchadvanced, identifier CRD42023476331.
This meta-analysis reveals Parkinson’s disease patients with RBD exhibit worse motor (UPDRS-III, Hoehn-Yahr), cognitive, and psychiatric symptoms (hallucinations, anxiety, depression, sleep disorders) due to overlapping pathology and broader neurodegeneration.
Rapid eye movement sleep behavior disorder and its relation to Parkinson's disease: The potential of graph measures as brain biomarkers to identify the underlying physiopathology of the disorder - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38494747/
Rapid eye movement behavior disorder (RBD) is a parasomnia characterized by the loss of skeletal muscle atonia during the rapid eye movement (REM) sleep phase. On the other hand, idiopathic...
Idiopathic RBD, a precursor to α-synucleinopathies, shows brain abnormalities in s-MRI, DWI, and fMRI studies. Graph metrics reveal segregation disorders in frontal/limbic regions, necessitating further longitudinal multicenter research.
Sleep extension and cardiometabolic health: what it is, possible mechanisms and real-world applications - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38268197/
Short sleep duration is associated with heightened cardiometabolic disease risk and has reached epidemic proportions among children, adolescents and adults. Potential mechanisms underlying this association are complex and multifaceted, including...
Short sleep duration increases cardiometabolic disease risk. Sleep extension may improve health, but existing studies have limitations. Future research should focus on long-term, randomized trials to determine effective interventions.
Sleep apnea and ischemic stroke- a perspective for translational preclinical modelling - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38581800/
Obstructive sleep apnea (OSA) is associated with ischemic stroke. There is, however, a lack of knowledge on the exact cause-effect relationship, and preclinical models of OSA for experimental ischemic stroke...
This review explores the link between obstructive sleep apnea (OSA) and ischemic stroke, highlighting metabolic syndrome and hypothalamic-pituitary axis dysfunction as key therapeutic targets, with a focus on improving preclinical models.
Novel biomarkers derived from the Maintenance of Wakefulness Test as predictors of sleepiness and response to treatment - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38954525/
The Maintenance of Wakefulness Test (MWT) is a widely accepted objective test used to evaluate daytime somnolence and is commonly used in clinical studies evaluating novel therapeutics for excessive daytime...
Danavorexton (TAK-925) reduced microsleeps and improved daytime wakefulness in narcolepsy. EEG-based biomarkers, including sleep probability measures and θ/α ratio, effectively tracked sleepiness and correlated with MWT outcomes.