High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1

Source : https://academic.oup.com/sleep/advance-article/doi/10.1093/sleep/zsab062/6168886?login=true

This is the first study to explore associations between clinical and sleep phenotype parameters, the P2RY11 polymorphism rs2305795 genotype, and P2Y 11 protein levels in a large mainly H1N1-(Pandemrix)-vaccinated cohort...

Polysomnographic Measures of Sleep Continuity in Patients With Narcolepsy: Results From the REST-ON Trial, a Pivotal Phase 3 Study of FT218, a Once-Nightly Sodium Oxybate Formulation (2461)

Source : https://n.neurology.org/content/96/15_Supplement/2461.abstract

Objective: To evaluate the efficacy of FT218, a once-nightly sodium oxybate (SO) formulation, on polysomnographic (PSG) measures of disturbed nocturnal sleep (DNS), including number of arousals (NAs), in patients with...

Effect of Sleep Disorders on Blood Pressure and Hypertension in Children

Source : https://link.springer.com/article/10.1007/s11906-020-01100-x

Purpose of Review In this review, we aim to discuss the pathophysiologic basis of hypertension in sleep disorders and the current evidence in the medical literature linking sleep disorders and...

Living with narcolepsy during adolescence: A qualitative study

Source : https://doi.org/10.1080/24745332.2021.1899088

RATIONALE: Narcolepsy is a chronic sleep disorder, with typical onset in childhood or adolescence. Features of narcolepsy include excessive daytime sleepiness (EDS), cataplexy, sleep paralysis, hallucinations and disturbed nocturnal sleep....

Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

Source : https://www.nature.com/articles/s41467-021-22637-8

Narcolepsy type 1 (NT1) is a severe sleep disorder with strong association to the HLA type DQB1*0602 and increased incidence among children vaccinated with the Influenza A vaccine Pandemrix. Here...