Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists
Source : https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c00841
Loss of orexin-producing neurons results in narcolepsy with cataplexy, and orexin agonists have been shown to increase wakefulness and alleviate narcolepsy symptoms in animal models. Several OX2R agonists have been...
Increased Chin Muscle Tone during All Sleep Stages in Children Taking SSRI Antidepressants and in Children with Narcolepsy Type 1
Source : https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsab147/6296039
You do not currently have access to this article. Subscription prices and ordering Don't already have an Oxford Academic account? Register Increased Chin Muscle Tone during All Sleep Stages in...
Symptom shift in 200 patients with H63D syndrome associated with abnormal TCS findings in substantia nigra
Source : https://doi.org/10.21203/rs.3.rs-564544/v1
In a study on the prevention of injury in patients with H63D syndrome and cataplexy, statistical analysis revealed an unexpected but clinically highly significant finding. Apparently, in this patient population,...
Efficacy and Safety of Lower-Sodium Oxybate in a Phase 3, Placebo-Controlled, Double-Blind, Randomized Withdrawal Study in Adult Participants With Idiopathic Hypersomnia (2659)
Source : https://n.neurology.org/content/96/15_Supplement/2659.abstract
Objective: Evaluate efficacy/safety of calcium, magnesium, potassium, and sodium oxybates (lower-sodium oxybate [LXB], Xywav™; previously designated JZP-258), a novel oxybate treatment with 92% less sodium than sodium oxybate (SXB; Xyrem®)...
Association of TNF-α (-308G/A) Gene Polymorphism with Circulating TNF-α Levels and Excessive Daytime Sleepiness in Adults with Coronary Artery Disease and Concomitant Obstructive Sleep Apnea
Source : https://www.atsjournals.org/doi/pdf/10.1164/ajrccm-conference.2021.203.1_MeetingAbstracts.A4713
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