Journal of Clinical Sleep Medicine
Source : https://doi.org/10.5664/jcsm.9792
Clinical benefits of PAP therapy for OSA are assumed to require adherent PAP usage, as defined by CMS as ≥ 4 hours of use ≥ 70% of nights. However, this...
Conclusions: Although sub-adherent PAP usage may still confer some benefit for OSA patients, adherence to current criteria confers the highest likelihood for ESS change and normalization.
Subjective symptoms and objective measures in idiopathic hypersomnia and hypersomnia associated with psychiatric disorders: a prospective cross-sectional study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34605393/
Study objectives: In some cases, it is difficult to correctly nosologically classify daytime sleepiness. Clinical manifestations may be non-specific, on the basis of objective measures it is possible to determine...
Conclusions: IH is a syndrome in which depression/external life stressors and personality characteristics also play a role. IH patients may benefit from the cooperation of sleep specialists with psychotherapists/psychiatrists.
Development of a lower-sodium oxybate formulation for the treatment of patients with narcolepsy and idiopathic hypersomnia
Source : https://doi.org/10.1080/17460441.2022.1999226
ABSTRACT ABSTRACT Sodium oxybate (SXB) is a standard of care for cataplexy, excessive daytime sleepiness, and disrupted nighttime sleep in narcolepsy. At recommended dosages in adults (6-9 g/night), SXB increases...
Expert Opinion: Reducing sodium from high sodium‒containing medications is an important step to offset cardiovascular risks associated with high sodium consumption. The development of LXB exemplifies the importance of a collaborative approach to drug development, with patient needs paramount.
Metabolomic Signature of Patients With Narcolepsy
Source : https://doi.org/10.1212/WNL.0000000000013128
Background and Objective: Narcolepsy type 1 (NT1) is an orphan brain disorder caused by the irreversible destruction of orexin neurons. Metabolic disturbances are common in patients with NT1 who have...
Discussion: These results represented the most comprehensive metabolic profiling of patients with NT1 as a function of BMI and propose some metabolic diagnostic biomarkers for NT1, namely glutamate, sarcosine, serotonin, tryptophan, nonaylcarnitine and some phosphatidylcholines. The metabolic pathways identified offer, if confirmed, possible...
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Sleep Disorder Connect4yrKey Points • Source: Nature Communications • Conclusions: “These results represented the most comprehensive metabolic profiling of patients with NT1 as a function of BMI and propose some metabolic diagnostic biomarkers for NT1, namely Show More
Increased Serum Prolactin and Excessive Daytime Sleepiness: An Attempt of Proof-of-Concept Study
Source : https://www.mdpi.com/2076-3425/11/12/1574
The objectives of this study were: (1) to identify subjects with hyperprolactinemia in a clinical sample of patients; (2) to compare the neurologic, psychiatric, and sleep conditions found in patients...
These findings can be considered as a preliminary indication of a role of hyperprolactinemia in EDS and represent a basis for future controlled studies able to test this hypothesis in a reliable, objective, and methodologically more appropriate way