Validation of the Epworth sleepiness scale for children and adolescents (ESS-CHAD) questionnaire in pediatric patients with narcolepsy with cataplexy aged 7-16 years
Source : https://www.sciencedirect.com/science/article/pii/S1389945721005529?via=ihub
Assessed validity of a daytime sleepiness scale modified for ages 7-16 years. * A sodium oxybate pediatric narcolepsy study was used to validate the modified scale. * Validity was assessed...
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Conclusion/Relevance: This evidence supports the validity of the 1-week ESS-CHAD in a pediatric population with narcolepsy.
Safety and efficacy of lower-sodium oxybate in adults with idiopathic hypersomnia: a phase 3, placebo-controlled, double-blind, randomised withdrawal study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34942138/
doi: 10.1016/S1474-4422(21)00368-9. 1 Sleep and Wake Disorders Centre, Department of Neurology, Gui de Chauliac Hospital, Montpellier, France; University of Montpellier, INSERM Institute Neuroscience Montpellier, Montpellier, France. Electronic address: [email protected]. 2...
Conclusion/Relevance: Lower-sodium oxybate treatment resulted in a clinically meaningful improvement in idiopathic hypersomnia symptoms, with an overall safety profile consistent with that reported for narcolepsy. Lower-sodium oxybate was approved in August, 2021, by the US Food and Drug Administration for the treatment of idiopathic...
Sleep disturbances in ADHD: investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34994865/
Sleep disturbances are common in attention deficit hyperactivity disorder (ADHD) and associated with poor outcomes. We tested whether, in children with ADHD, (1) polygenic liability for sleep phenotypes is over-...
Conclusion/Relevance: There is weak evidence that children with ADHD over-inherit polygenic liability for longer sleep duration and do not differentially inherit polygenic liability for insomnia or chronotype. There was insufficient evidence that childhood sleep disturbances were driven by polygenic liability for ADHD or sleep traits,...
The sleep quality and sleep-related issue in industrial workers: A global Meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34970939/
doi: 10.1080/10803548.2021.2024376. Online ahead of print. 1 Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. E-mail: [email protected]; [email protected]. 2 Behavioral Sciences Research Center, Lifestyle Institute,...
Conclusion/Relevance: Sleep-related issues have a high prevalence prevalent in industrial workers, and the cause of these differences needs to be addressed and increasing insights provided to prevent and treat sleep disorders.
Insomnia and depressive behavior of MyD88-deficient mice: Relationships with altered microglial functions - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34971898/
Myeloid differentiation primary response gene 88 (MyD88) is essential for microglial activation. Despite the significant role of microglia in regulating sleep homeostasis, the contribution of MyD88 to sleep is yet...
Conclusion/Relevance: These findings indicate that genetic deletion of MyD88 induces insomnia and depressive behavior, at least in part, by affecting microglial homeostasis functions and lowering the serotonergic neuronal output.