Automatic Detection of the Cyclic Alternating Pattern of Sleep and Diagnosis of Sleep-Related Pathologies Based on Cardiopulmonary Resonance Indices - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35336396/
The cyclic alternating pattern is the periodic electroencephalogram activity occurring during non-rapid eye movement sleep. It is a marker of sleep instability and is correlated with several sleep-related pathologies. Considering...
Relevance:The cyclic alternating pattern is the periodic electroencephalogram activity occurring during non-rapid eye movement sleep. It is a marker of sleep instability and is correlated with several sleep-related pathologies.
The contribution of daytime sleepiness to impaired quality of life in NAFLD in an ethnically diverse population - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-08358-y
Health-related quality of life (HRQoL) is lower in people with NAFLD compared to the general population. Sleep disturbance resulting in daytime sleepiness is common in patients with NAFLD, but the...
Conclusion: Daytime sleepiness should be considered as a contributing factor to reduced HRQoL in clinical practice and when evaluating patient-related outcomes in clinical trials.
Assessment of the effect of the dual orexin receptor antagonist daridorexant on various indices of disease severity in patients with mild to moderate obstructive sleep apnea - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35306405/
doi: 10.1016/j.sleep.2021.11.015. Online ahead of print. 1 Idorsia Pharmaceuticals Ltd, Department of Clinical Pharmacology, Allschwil, Switzerland. Electronic address: [email protected]. 2 Idorsia Pharmaceuticals Ltd, Department of Clinical Pharmacology, Allschwil, Switzerland. 3...
Conclusion: These results suggest safe use of daridorexant in patients with mild to moderate OSA.
Evaluating the risk of toxicity and adverse drug interactions involving recreational GHB use and prescribed drugs
Source : https://www.tandfonline.com/doi/abs/10.1080/17425255.2021.2029404?journalCode=iemt20
ABSTRACT GHB is a small molecule and is present in the human CNS. Exogenously, GHB is administered orally in the form of sodium oxybate to treat cataplexy and excessive daytime...
Expert opinion: Due to its dual nature, interpreting and distinguishing GHB concentrations in biological fluid represents a challenge in forensic toxicology. To demonstrate recent exposure, a quick collection of samples is necessary to maximize the chance of detecting an exogenous GHB intake, especially in cases of GHB-facilitated sexual...
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Dr Hamid4yrKnowledge of the potential interactions of GHB and its analogues with prescribed drugs is crucial to minimize potential acute GHB toxicity.
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Sleep Disorder Connect4yrKey Points • Source: Expert Opinion in Drug Metabolism & Toxicology • Conclusions. “Due to its dual nature, interpreting and distinguishing GHB concentrations in biological fluid represents a challenge in forensic toxicology. To demonstrate Show More
LMOD3 gene variant in familial periodic hypersomnolence - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35299092/
We report the association of periodic hypersomnia with a polymorphism of the LMOD3-gene in a patient with atypical KLS and a positive family history. Further research is needed to assess...
Discussion: We report the association of periodic hypersomnia with a polymorphism of the LMOD3-gene in a patient with atypical KLS and a positive family history. Further research is needed to assess the pathological and predictive value of LMOD3 variants in KLS.