9mo
Disease Spotlight
Agitation in Alzheimer's Dementia
9mo
An Overview of the Effects of Lithium on Alzheimer's Disease: A Historical Perspective - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40283967/
Lithium was introduced into psychiatric practice in the late nineteenth century and has since become a standard treatment for severe psychiatric disorders, particularly those characterized by psychotic agitation. It remains...
A historical review of lithium's psychiatric use, highlighting its neuroprotective properties and potential therapeutic role in Alzheimer’s disease, with implications for managing neuropsychiatric symptoms like agitation.
9mo
Treatment of agitation in dementia - a systematic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40414837/
Dementia, including Alzheimer's disease (AD), affects millions worldwide, leading to cognitive decline, memory loss, and behavioral disturbances. Agitation, a common symptom, poses significant challenges for patients and caregivers. This systematic...
This systematic review evaluates treatments for agitation in dementia, highlighting brexpiprazole’s dose-dependent efficacy among pharmacologic options, and emphasizing the value of individualized, holistic approaches including non-drug therapies.
9mo
Mixed methods feasibility study of Music Attuned Technology Care via eHealth (MATCH) for people with complex behavioral and psychological symptoms of dementia within an acute psychogeriatric ward - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40317914/
MATCH decreased the severity of dementia symptoms, measured by the NPI-Q. Staff reported high acceptability of MATCH. Personalized music enhanced person-centered care. Patients' positive responses to music motivated increased use....
This feasibility study found that MATCH, a music-based eHealth intervention, reduced agitation and other symptoms in dementia patients, with high staff acceptance and enhanced person-centered care in acute settings.
9mo
Treatment of Restless Legs Syndrome Improves Agitation and Sleep in Persons with Dementia: A Randomized Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39909068/
Our findings suggest a novel approach for nighttime agitation in persons with dementia: assessing for RLS and initiating interventions. Larger and longer trials are needed.
Treating RLS with gabapentin enacarbil significantly reduced nighttime agitation and improved sleep in dementia patients, suggesting RLS screening and treatment as a novel strategy for managing Alzheimer’s-related agitation.