Amyloid-related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid-modifying therapy
Source : https://pubmed.ncbi.nlm.nih.gov/38939962/
Amyloid-related imaging abnormalities, were originally described by dementia care experts. The wider use of aducanumab and now lecanemab warrant broader understanding by the health care provider continuum. The optimal care...
As with some other neurological conditions, the greater the preexisting pathology, the greater the potential benefit of some treatment, but as well the commensurate risk of potential adverse effects. Patient risk stratification is improved by focusing on genetic risk profile-APOE4/4 homozygosity, cerebral amyloid burden, necessity of...
Sex differences in the relationship between depression and Alzheimer's disease-mechanisms, genetics, and therapeutic opportunities
Source : https://pubmed.ncbi.nlm.nih.gov/38903903/
Depression and Alzheimer's disease (AD) are prevalent neuropsychiatric disorders with intriguing epidemiological overlaps. Their interrelation has recently garnered widespread attention. Empirical evidence indicates that depressive disorders significantly contribute to AD...
Accumulating evidence supports the significant influence of sex on depression and AD. Specifically, women experience higher prevalence of both conditions than men do, possibly leading to differences in treatment outcome (Hampel et al., 2018; Wang et al., 2022a; Cui et al., 2023; Tseng et al., 2023), suggesting the imperative of crafting...
Association between sleep apnoea and risk of cognitive impairment and Alzheimer's disease: a meta-analysis of cohort-based studies
Source : https://pubmed.ncbi.nlm.nih.gov/37857768/
Findings suggest a possible association of SDB/OSA with risk of all-cause cognitive impairment and/or dementia. However, careful interpretation is warranted as the majority of the studies did not rely on...
Findings suggest a possible association of SDB/OSA with risk of all-cause cognitive impairment and/or dementia. However, careful interpretation is warranted as the majority of the studies did not rely on objective assessment based on polysomnography.
Evaluation of the Neuroprotective Effect of Organic Selenium Compounds: An in Vitro Model of Alzheimer's Disease
Source : https://pubmed.ncbi.nlm.nih.gov/37803188/
Selenium (Se) is an essential trace element for human health and plays an important role in the development and maintenance of central nervous system functions. Se deficiency has been associated...
The neuroprotective effect of organic Se compounds, selenomethionine (SeMet) and Ebselen, was evaluated through cell viability tests, acetylcholinesterase and antioxidant enzyme activities, and detection of reactive oxygen species (ROS). None of the SeMet concentrations tested protected against the toxic effect of OA + Aβ. On the other hand,...
Personalized hippocampal network–targeted stimulation could be considered as a viable nonpharmacological treatment of Alzheimer disease.